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Undetectable serum anti-Müllerian hormone levels and occurrence of ongoing pregnancy

Fraisse, Timothée
Ibecheole, Victoria
Streuli, Isabelle
Published in Fertility and Sterility. 2008, vol. 89, no. 3, p. 723.e9-11
Abstract OBJECTIVE: To discuss, on the basis of the experience of two clinical cases and extensive literature review, the significance of extremely low levels of anti-Müllerian hormone (AMH), also known as Müllerian-inhibiting substance, in infertile women. DESIGN: Case report. SETTING: University-based infertility clinic at a medical center in Switzerland. PATIENT(S): Two women, 29 and 41 years of age and with a 2- and 4-year history of secondary infertility, respectively. INTERVENTION(S): Clinical, radiological, and biological investigation of infertility, including repeated measurements of the serum AMH with serial ELISA assays. MAIN OUTCOME MEASURE(S): Levels of AMH and development of ongoing pregnancy. RESULT(S): Both women had a spontaneous ongoing pregnancy despite undetectable AMH levels. CONCLUSION(S): Although it is helpful for day-to-day management of infertile patients, the predictive value of AMH for the occurrence of a spontaneous ongoing pregnancy has limits.
Keywords AdultAnti-Mullerian Hormone/bloodBiological Markers/bloodEnzyme-Linked Immunosorbent AssayFemaleFertilityHumansInfertility Female/blood/physiopathologyPredictive Value of TestsPregnancyReproducibility of Results
PMID: 17562340
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FRAISSE, Timothée et al. Undetectable serum anti-Müllerian hormone levels and occurrence of ongoing pregnancy. In: Fertility and Sterility, 2008, vol. 89, n° 3, p. 723.e9-11. https://archive-ouverte.unige.ch/unige:761

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Deposited on : 2009-02-11

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