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Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa

Tateda, K.
Comte, R.
Yamaguchi, K.
Published in Antimicrobial agents and chemotherapy. 2001, vol. 45, no. 6, p. 1930-1933
Abstract We report that 2 microg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.
Keywords Anti-Bacterial Agents/ pharmacologyAzithromycin/ pharmacologyBacterial Proteins/ drug effectsDNA-Binding Proteins/drug effectsLac Operon/drug effectsMembrane Transport ProteinsPseudomonas aeruginosa/ drug effectsTrans-Activators/drug effects
PMID: 11353657
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TATEDA, K. et al. Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa. In: Antimicrobial agents and chemotherapy, 2001, vol. 45, n° 6, p. 1930-1933. doi: 10.1128/AAC.45.6.1930-1933.2001 https://archive-ouverte.unige.ch/unige:7604

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Deposited on : 2010-06-21

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