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Structural and functional connectivity in the default mode network in 22q11.2 deletion syndrome

Contributors

Padula, Maria; Schaer, Marie; Scariati Jaussi, Elisa; Schneider, Maude; Van De Ville, Dimitri; Debbané, Martin; Eliez, Stéphan

Published in

Journal of neurodevelopmental disorders, vol. 7, no. 1, 23

Publication date

2015

Abstract

The neural endophenotype associated with 22q11.2 deletion syndrome (22q11DS) includes deviant cortical development and alterations in brain connectivity. Resting-state functional magnetic resonance imaging (fMRI) findings also reported disconnectivity within the default mode network (DMN). In this study, we explored the relationship between functional and structural DMN connectivity and their changes with age in patients with 22q11DS in comparison to control participants. Given previous evidence of an association between DMN disconnectivity and the manifestation of psychotic symptoms, we further investigated this relationship in our group of patients with 22q11DS.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

PADULA, Maria et al. Structural and functional connectivity in the default mode network in 22q11.2 deletion syndrome. In: Journal of neurodevelopmental disorders, 2015, vol. 7, n° 1, p. 23. doi: 10.1186/s11689-015-9120-y

Main files (1)

Article (Published version)

Identifiers

Additional URL for this publication

http://www.jneurodevdisorders.com/content/7/1/23

Journal ISSN

1866-1947
699views
280downloads

Technical informations

Creation

02/09/2015 15:29:00

First validation

02/09/2015 15:29:00

Update

13/10/2025 21:13:30

Status update

14/03/2023 23:41:25

Last indexation

01/09/2026 08:20:47
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