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Striatum and entorhinal cortex atrophy in AD mouse models: MRI comprehensive analysis

Micotti, Edoardo
Paladini, Alessandra
Balducci, Claudia
Tolomeo, Daniele
Frasca, Angelisa
Marizzoni, Moira
Filibian, Marta
Caroli, Anna
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Published in Neurobiology of Aging. 2015, vol. 36, no. 2, p. 776-788
Abstract Alzheimer's disease is experimentally modeled in transgenic (Tg) mice overexpressing mutated forms of the human amyloid precursor protein either alone or combined with mutated presenilins and tau. In the present study, we developed a systematic approach to compare double (TASTPM) and triple (APP/PS2/Tau) Tg mice by serial magnetic resonance imaging and spectroscopy analysis from 4 to 26 months of age to define homologous biomarkers between mice and humans. Hippocampal atrophy was found in Tg mice compared with WT. In APP/PS2/Tau the effect was age-dependent, whereas in TASTPM it was detectable from the first investigated time point. Importantly, both mice displayed an age-related entorhinal cortex thinning and robust striatal atrophy, the latter associated with a significant loss of synaptophysin. Hippocampal magnetic resonance spectroscopy revealed lower glutamate levels in both Tg mice and a selective myo-inositol increase in TASTPM. This noninvasive magnetic resonance imaging analysis, revealed common biomarkers between humans and mice, and could, thus, be promoted as a fully translational tool to be adopted in the preclinical investigation of therapeutic approaches.
PMID: 25433456
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Research group Troubles de mémoire et maladie d'Alzeimer (935)
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MICOTTI, Edoardo et al. Striatum and entorhinal cortex atrophy in AD mouse models: MRI comprehensive analysis. In: Neurobiology of Aging, 2015, vol. 36, n° 2, p. 776-788. https://archive-ouverte.unige.ch/unige:75909

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Deposited on : 2015-10-09

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