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Scientific article
English

Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis

Published inLancet neurology, vol. 14, no. 3, p. 253-262
Publication date2015
Abstract

Frontotemporal dementia is a highly heritable neurodegenerative disorder. In about a third of patients, the disease is caused by autosomal dominant genetic mutations usually in one of three genes: progranulin (GRN), microtubule-associated protein tau (MAPT), or chromosome 9 open reading frame 72 (C9orf72). Findings from studies of other genetic dementias have shown neuroimaging and cognitive changes before symptoms onset, and we aimed to identify whether such changes could be shown in frontotemporal dementia.

Keywords
  • Adult
  • Asymptomatic Diseases
  • Brain/pathology
  • Cognition Disorders/diagnosis/genetics/psychology
  • Cross-Sectional Studies
  • Female
  • Frontotemporal Dementia/diagnosis/genetics/psychology
  • Humans
  • Male
  • Middle Aged
  • Mutation/genetics
  • Neuropsychological Tests
Citation (ISO format)
ROHRER, Jonathan D, FRISONI, Giovanni. Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis. In: Lancet neurology, 2015, vol. 14, n° 3, p. 253–262. doi: 10.1016/S1474-4422(14)70324-2
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ISSN of the journal1474-4422
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Creation08/25/2015 3:37:00 PM
First validation08/25/2015 3:37:00 PM
Update time03/14/2023 11:41:04 PM
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