Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly

Marizzoni, Moira; Antelmi, Luigi; Bosch, Beatriz; Bartrés-Faz, David; Müller, Bernhard W; Wiltfang, Jens; Fiedler, Ute; Roccatagliata, Luca; Picco, Agnese; Nobili, Flavio; Blin, Olivier; Bombois, Stephanie; Lopes, Renaud; Sein, Julien; Ranjeva, Jean-Philippe; Didic, Mira; Gros-Dagnac, Hélène; Payoux, Pierre; Zoccatelli, Giada; Alessandrini, Franco; Beltramello, Alberto; Bargalló, Núria; Ferretti, Antonio; Caulo, Massimo; Aiello, Marco; Cavaliere, Carlo; Soricelli, Andrea; Salvadori, Nicola; Parnetti, Lucilla; Tarducci, Roberto; Floridi, Piero; Tsolaki, Magda; Constantinidis, Manos; Drevelegas, Antonios; Rossini, Paolo Maria; Marra, Camillo; Hoffmann, Karl-Titus; Hensch, Tilman; Schönknecht, Peter; Kuijer, Joost P; Visser, Pieter Jelle; Barkhof, Frederik; Bordet, Régis; Frisoni, Giovanni; Jovicich, Jorge

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Title		Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly
Authors		Marizzoni, Moira Antelmi, Luigi Bosch, Beatriz Bartrés-Faz, David Müller, Bernhard W Wiltfang, Jens Fiedler, Ute Roccatagliata, Luca Picco, Agnese Nobili, Flavio Blin, Olivier Bombois, Stephanie Lopes, Renaud Sein, Julien Ranjeva, Jean-Philippe Didic, Mira Gros-Dagnac, Hélène Payoux, Pierre Zoccatelli, Giada Alessandrini, Franco Beltramello, Alberto Bargalló, Núria Ferretti, Antonio Caulo, Massimo Aiello, Marco Cavaliere, Carlo Soricelli, Andrea Salvadori, Nicola Parnetti, Lucilla Tarducci, Roberto Floridi, Piero Tsolaki, Magda Constantinidis, Manos Drevelegas, Antonios Rossini, Paolo Maria Marra, Camillo Hoffmann, Karl-Titus Hensch, Tilman Schönknecht, Peter Kuijer, Joost P Visser, Pieter Jelle Barkhof, Frederik Bordet, Régis Frisoni, Giovanni Jovicich, Jorge show all authors [1 - 45]
Published in		Human Brain Mapping. 2015, vol. 36, no. 9, p. 3516-3527
Abstract		Recently, there has been an increased interest in the use of automatically segmented subfields of the human hippocampal formation derived from magnetic resonance imaging (MRI). However, little is known about the test-retest reproducibility of such measures, particularly in the context of multisite studies. Here, we report the reproducibility of automated Freesurfer hippocampal subfields segmentations in 65 healthy elderly enrolled in a consortium of 13 3T MRI sites (five subjects per site). Participants were scanned in two sessions (test and retest) at least one week apart. Each session included two anatomical 3D T1 MRI acquisitions harmonized in the consortium. We evaluated the test-retest reproducibility of subfields segmentation (i) to assess the effects of averaging two within-session T1 images and (ii) to compare subfields with whole hippocampus volume and spatial reliability. We found that within-session averaging of two T1 images significantly improved the reproducibility of all hippocampal subfields but not that of the whole hippocampus. Volumetric and spatial reproducibility across MRI sites were very good for the whole hippocampus, CA2-3, CA4-dentate gyrus (DG), subiculum (reproducibility error∼2% and DICE > 0.90), good for CA1 and presubiculum (reproducibility error ∼ 5% and DICE ∼ 0.90), and poorer for fimbria and hippocampal fissure (reproducibility error ∼ 15% and DICE < 0.80). Spearman's correlations confirmed that test-retest reproducibility improved with volume size. Despite considerable differences of MRI scanner configurations, we found consistent hippocampal subfields volumes estimation. CA2-3, CA4-DG, and sub-CA1 (subiculum, presubiculum, and CA1 pooled together) gave test-retest reproducibility similar to the whole hippocampus. Our findings suggest that the larger hippocampal subfields volume may be reliable longitudinal markers in multisite studies. Hum Brain Mapp, 2015. © 2015 Wiley Periodicals, Inc.
Identifiers		DOI: 10.1002/hbm.22859 PMID: 26043939
Full text		Article (Published version) (562 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research group		Troubles de mémoire et maladie d'Alzeimer (935)
Citation (ISO format)		MARIZZONI, Moira et al. Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly. In: Human Brain Mapping, 2015, vol. 36, n° 9, p. 3516-3527. https://archive-ouverte.unige.ch/unige:75875