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Scientific article
Open access
English

Sunitinib-eluting beads for chemoembolization: Methods for in vitro evaluation of drug release

Published inInternational journal of pharmaceutics, vol. 482, no. 1-2, p. 68-74
Publication date2015
Abstract

Drug-eluting microspheres are used for embolization of hypervascular tumors and allow for local controlled drug release. Although the drug release from the microspheres relies on fast ion-exchange, so far only slow-releasing in vitro dissolution methods have been correlated to in vivo data. Three in vitro release methods are assessed in this study for their potential to predict slow in vivo release of sunitinib from chemoembolization spheres to the plasma, and fast local in vivo release obtained in an earlier study in rabbits. Release in an orbital shaker was slow (t50% = 4.5 h, 84% release) compared to fast release in USP 4 flow-through implant cells (t50% = 1 h, 100% release). Release of sunitinib from microspheres in saline in dialysis inserts was prolonged and incomplete (t50% = 9 d, 68% release) due to low drug diffusion through the dialysis membrane. The slow-release profile fitted best to low sunitinib plasma AUC following injection of sunitinib-eluting spheres. Although limited by lack of standardization, release in the orbital shaker fitted best to local in vivo sunitinib concentrations. Drug release in USP flow-through implant cells was too fast to correlate with local concentrations, although this method is preferred to discriminate between different sphere types.

Keywords
  • In vitro drug release
  • Sunitinib
  • Drug-eluting beads
  • USP dissolution apparatus 4
  • Chemoembolization
  • In vitro-in vivo correlation
Research group
Funding
  • Autre - DIP
Citation (ISO format)
FUCHS, Katrin et al. Sunitinib-eluting beads for chemoembolization: Methods for in vitro evaluation of drug release. In: International journal of pharmaceutics, 2015, vol. 482, n° 1-2, p. 68–74. doi: 10.1016/j.ijpharm.2014.11.041
Main files (1)
Article (Accepted version)
accessLevelPublic
Identifiers
ISSN of the journal0378-5173
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600downloads

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