UNIGE document Privat-docent Thesis
previous document  unige:75473  next document
add to browser collection
Title

Neuroanatomical and Neuropsychological Features of Elderly Euthymic Patients With Bipolar Disorder or Early-Onset Depression

Author
Defense Thèse de privat-docent : Univ. Genève, 2013
Abstract We explored whether chronic mood disorder has a long-term «toxic effect» on cognition and brain structures. We performed a 2-year longitudinal study of four groups of elderly individuals: euthymic patients suffering from bipolar disorder (BD), euthymic patients presenting an early (EOD) or a late-onset (LOD) of depression and healthy elderly. Regarding BD, patients displayed significantly lower performances in processing speed and episodic memory but not in working memory and executive functions compared to controls. However, BD patients did not differ from controls in the mean trajectory of cognitive changes during the two years follow-up. In the same line, longitudinal grey matter and white matter changes did not differ between BD patients and controls. Our results suggest that BD does not have a significant adverse impact. Regarding EOD, results revealed that cognitive performances as well as brain volumes were preserved in EOD patients both at baseline and at follow-up. LOD patients showed decreased performances limited to episodic memory tasks. Besides, MRI analyses found that they had significantly greater periventricular hyperintensities than controls. Our results support the distinction between the aetiological mechanisms implicated in the pathogenesis of LOD and EOD.
Keywords AgingElderlyBipolar disorderUnipolar depressionCognitionStructural imaging
Identifiers
Full text
Thesis (36.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Citation
(ISO format)
DELALOYE, Christophe. Neuroanatomical and Neuropsychological Features of Elderly Euthymic Patients With Bipolar Disorder or Early-Onset Depression. Université de Genève. Thèse de privat-docent, 2013. https://archive-ouverte.unige.ch/unige:75473

161 hits

3 downloads

Update

Deposited on : 2015-09-29

Export document
Format :
Citation style :