Scientific article
Open access

Evasion of innate and adaptive immune responses by influenza A virus

Published inCellular microbiology, vol. 12, no. 7, p. 873-880
Publication date2010

Host organisms have developed sophisticated antiviral responses in order to defeat emerging influenza A viruses (IAVs). At the same time IAVs have evolved immune evasion strategies. The immune system of mammals provides several lines of defence to neutralize invading pathogens or limit their replication. Here, we summarize the mammalian innate and adaptive immune mechanisms involved in host defence against viral infection and review strategies by which IAVs avoid, circumvent or subvert these mechanisms. We highlight well-characterized, as well as recently described features of this intriguing virus-host molecular battle.

  • Adaptive Immunity/immunology
  • Animals
  • Humans
  • Immune Evasion/immunology
  • Immunity, Innate/immunology
  • Influenza A virus/genetics/immunology/metabolism
  • Signal Transduction/genetics/immunology/physiology
Affiliation Not a UNIGE publication
Citation (ISO format)
SCHMOLKE, Mirco, GARCÍA-SASTRE, Adolfo. Evasion of innate and adaptive immune responses by influenza A virus. In: Cellular microbiology, 2010, vol. 12, n° 7, p. 873–880. doi: 10.1111/j.1462-5822.2010.01475.x
Main files (1)
Article (Published version)
ISSN of the journal1462-5814

Technical informations

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