Scientific Article
previous document  unige:75380  next document
add to browser collection

Evasion of innate and adaptive immune responses by influenza A virus

García-Sastre, Adolfo
Published in Cellular Microbiology. 2010, vol. 12, no. 7, p. 873-880
Abstract Host organisms have developed sophisticated antiviral responses in order to defeat emerging influenza A viruses (IAVs). At the same time IAVs have evolved immune evasion strategies. The immune system of mammals provides several lines of defence to neutralize invading pathogens or limit their replication. Here, we summarize the mammalian innate and adaptive immune mechanisms involved in host defence against viral infection and review strategies by which IAVs avoid, circumvent or subvert these mechanisms. We highlight well-characterized, as well as recently described features of this intriguing virus-host molecular battle.
Keywords Adaptive Immunity/immunologyAnimalsHumansImmune Evasion/immunologyImmunity, Innate/immunologyInfluenza A virus/genetics/immunology/metabolismSignal Transduction/genetics/immunology/physiology
PMID: 20482552
Full text
Article (Published version) (861 Kb) - public document Free access
(ISO format)
SCHMOLKE, Mirco, GARCÍA-SASTRE, Adolfo. Evasion of innate and adaptive immune responses by influenza A virus. In: Cellular Microbiology, 2010, vol. 12, n° 7, p. 873-880. doi: 10.1111/j.1462-5822.2010.01475.x

378 hits



Deposited on : 2015-09-25

Export document
Format :
Citation style :