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Neuronal pattern separation in the olfactory bulb improves odor discrimination learning

Begnaud, Frédéric
Published in Nature Neuroscience. 2015, vol. 18, no. 10, p. 1474-1482
Abstract Neuronal pattern separation is thought to enable the brain to disambiguate sensory stimuli with overlapping features, thereby extracting valuable information. In the olfactory system, it remains unknown whether pattern separation acts as a driving force for sensory discrimination and the learning thereof. We found that overlapping odor-evoked input patterns to the mouse olfactory bulb (OB) were dynamically reformatted in the network on the timescale of a single breath, giving rise to separated patterns of activity in an ensemble of output neurons, mitral/tufted (M/T) cells. Notably, the extent of pattern separation in M/T assemblies predicted behavioral discrimination performance during the learning phase. Furthermore, exciting or inhibiting GABAergic OB interneurons, using optogenetics or pharmacogenetics, altered pattern separation and thereby odor discrimination learning in a bidirectional way. In conclusion, we propose that the OB network can act as a pattern separator facilitating olfactory stimulus distinction, a process that is sculpted by synaptic inhibition.
Keywords Pattern separationOptogeneticChemogeneticLearningBehaviorOlfaction
PMID: 26301325
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Article (Published version) (4.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Groupe Carleton Alan (neurosciences fondamentales) (876)
Groupe Rodriguez
Projects FNS: 31003A_153410
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GSCHWEND, Olivier et al. Neuronal pattern separation in the olfactory bulb improves odor discrimination learning. In: Nature Neuroscience, 2015, vol. 18, n° 10, p. 1474-1482. doi: 10.1038/nn.4089 https://archive-ouverte.unige.ch/unige:75227

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Deposited on : 2015-09-16

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