UNIGE document Scientific Article
previous document  unige:75001  next document
add to browser collection
Title

Sensory-Evoked Intrinsic Imaging Signals in the Olfactory Bulb Are Independent of Neurovascular Coupling

Authors
Van De Ville, Dimitri
Published in Cell Reports. 2015, vol. 12, no. 2, p. 313-325
Abstract Functional brain-imaging techniques used in humans and animals, such as functional MRI and intrinsic optical signal (IOS) imaging, are thought to largely rely on neurovascular coupling and hemodynamic responses. Here, taking advantage of the well described micro-architecture of the mouse olfactory bulb, we dissected the nature of odor-evoked IOSs. Using in vivo pharmacology in transgenic mouse lines reporting activity in different cell types, we show that parenchymal IOSs are largely independent of neurotransmitter release and neurovascular coupling. Furthermore, our results suggest that odor-evoked parenchymal IOSs originate from changes in light scattering of olfactory sensory neuron axons, mostly due to water movement following action potential propagation. Our study sheds light on a direct correlate of neuronal activity, which may be used for large-scale functional brain imaging.
Keywords Functional brain imagingAxon swelling
Identifiers
PMID: 26146075
Full text
Structures
Research groups Groupe Carleton Alan (neurosciences fondamentales) (876)
Groupe Rodriguez
Traitement d'images médicales (893)
Projects FNS: 31003A_153410
FP7: NEUROCHEMS
Citation
(ISO format)
VINCIS, Roberto et al. Sensory-Evoked Intrinsic Imaging Signals in the Olfactory Bulb Are Independent of Neurovascular Coupling. In: Cell Reports, 2015, vol. 12, n° 2, p. 313-325. https://archive-ouverte.unige.ch/unige:75001

166 hits

76 downloads

Update

Deposited on : 2015-09-02

Export document
Format :
Citation style :