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Infliximab then efalizumab, the 'hit and run' approach does not work

Barde, Caroline
Thielen, A M.
Published in Dermatology (Basel, Switzerland). 2008, vol. 216, no. 2, p. 171-2
Abstract BACKGROUND: In a previous paper we described 2 patients treated with a sequential biologic therapy for chronic plaque psoriasis. We used infliximab as an induction treatment followed by efalizumab. We extended this approach to 3 other patients. OBJECTIVE: The purpose was to show the feasibility of a sequential approach with biologicals. METHODS: Five patients received three infusions of infliximab followed by weekly injections of efalizumab from week 10 on. RESULTS: The most important findings, summarized in a table, show that none of the patients continued the treatment for more than a year either because of non-responsiveness or because of spontaneous stopping. Moreover, 4 out of 5 patients did not respond or had serious adverse events on reintroduction of infliximab. CONCLUSION: Overall, we cannot recommend sequential therapy using infliximab and efalizumab.
Keywords AdultAntibodies Monoclonal/therapeutic useCell Migration InhibitionDermatologic Agents/therapeutic useDisease ProgressionFollow-Up StudiesHumansMaleMiddle AgedPsoriasis/drug therapyTime FactorsTumor Necrosis Factor-alpha
PMID: 18216482
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Research groups La recherche en biochimie dermatologique (652)
Rôle du CD44 (809)
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BARDE, Caroline, THIELEN, A M., SAURAT, Jean-Hilaire. Infliximab then efalizumab, the 'hit and run' approach does not work. In: Dermatology, 2008, vol. 216, n° 2, p. 171-2. https://archive-ouverte.unige.ch/unige:749

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Deposited on : 2009-02-11

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