en
Scientific article
Open access
English

Wnt signaling regulates multipolar-to-bipolar transition of migrating neurons in the cerebral cortex

Published inCell reports, vol. 10, no. 8, p. 1349-1361
Publication date2015
Abstract

The precise timing of pyramidal cell migration from the ventricular germinal zone to the cortical plate is essential for establishing cortical layers, and migration errors can lead to neurodevelopmental disorders underlying psychiatric and neurological diseases. Here, we report that Wnt canonical as well as non-canonical signaling is active in pyramidal precursors during radial migration. We demonstrate using constitutive and conditional genetic strategies that transient downregulation of canonical Wnt/β-catenin signaling during the multipolar stage plays a critical role in polarizing and orienting cells for radial migration. In addition, we show that reduced canonical Wnt signaling is triggered cell autonomously by time-dependent expression of Wnt5A and activation of non-canonical signaling. We identify ephrin-B1 as a canonical Wnt-signaling-regulated target in control of the multipolar-to-bipolar switch. These findings highlight the critical role of Wnt signaling activity in neuronal positioning during cortical development.

Citation (ISO format)
BOITARD, Michael et al. Wnt signaling regulates multipolar-to-bipolar transition of migrating neurons in the cerebral cortex. In: Cell reports, 2015, vol. 10, n° 8, p. 1349–1361. doi: 10.1016/j.celrep.2015.01.061
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal2211-1247
618views
237downloads

Technical informations

Creation07/31/2015 11:14:00 AM
First validation07/31/2015 11:14:00 AM
Update time03/14/2023 11:34:22 PM
Status update03/14/2023 11:34:22 PM
Last indexation01/16/2024 6:47:13 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack