Scientific article
OA Policy
English

Role of cholecystokinin in corticotropin release: coexistence with vasopressin and corticotropin-releasing factor in cells of the rat hypothalamic paraventricular nucleus

Publication date1986
Abstract

Cholecystokinin-8 (CCK8)-containing cell bodies in the parvocellular region of the rat paraventricular nucleus (PVN) contain vasopressin and corticotropin-releasing factor (CRF). The CCK8 and vasopressin in these cells can readily be visualized in adrenalectomized, but not in shamoperated animals. Furthermore, CCK8 levels as measured by RIA change in the PVN and in the median eminence in response to adrenalectomy. CCK8 has a stimulatory effect on corticotropin (ACTH) release from primary cultures of the anterior pituitary. This stimulation is additive with that produced by vasopressin; CCK8 plus vasopressin have an effect as great as CRF in stimulating ACTH release. Our results suggest that CCK8 may participate in the regulation of ACTH release under certain physiological conditions.

Keywords
  • Adrenalectomy
  • Adrenocorticotropic Hormone/secretion
  • Animals
  • Cells, Cultured
  • Cholecystokinin/physiology
  • Corticotropin-Releasing Hormone/metabolism
  • Fluorescent Antibody Technique
  • Male
  • Paraventricular Hypothalamic Nucleus/metabolism
  • Pituitary Gland, Anterior/secretion
  • Rats
  • Secretory Rate
  • Vasopressins/metabolism
Citation (ISO format)
MEZEY, E et al. Role of cholecystokinin in corticotropin release: coexistence with vasopressin and corticotropin-releasing factor in cells of the rat hypothalamic paraventricular nucleus. In: Proceedings of the National Academy of Sciences of the United States of America, 1986, vol. 83, n° 10, p. 3510–3512.
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN0027-8424
502views
233downloads

Technical informations

Creation31/07/2015 15:44:00
First validation31/07/2015 15:44:00
Update time14/03/2023 23:34:18
Status update14/03/2023 23:34:18
Last indexation31/10/2024 01:06:17
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack