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Title

Role of cholecystokinin in corticotropin release: coexistence with vasopressin and corticotropin-releasing factor in cells of the rat hypothalamic paraventricular nucleus

Authors
Mezey, E
Reisine, T D
Skirboll, L
Beinfeld, M
Published in Proceedings of the National Academy of Sciences. 1986, vol. 83, no. 10, p. 3510-2
Abstract Cholecystokinin-8 (CCK8)-containing cell bodies in the parvocellular region of the rat paraventricular nucleus (PVN) contain vasopressin and corticotropin-releasing factor (CRF). The CCK8 and vasopressin in these cells can readily be visualized in adrenalectomized, but not in shamoperated animals. Furthermore, CCK8 levels as measured by RIA change in the PVN and in the median eminence in response to adrenalectomy. CCK8 has a stimulatory effect on corticotropin (ACTH) release from primary cultures of the anterior pituitary. This stimulation is additive with that produced by vasopressin; CCK8 plus vasopressin have an effect as great as CRF in stimulating ACTH release. Our results suggest that CCK8 may participate in the regulation of ACTH release under certain physiological conditions.
Keywords AdrenalectomyAdrenocorticotropic Hormone/secretionAnimalsCells, CulturedCholecystokinin/physiologyCorticotropin-Releasing Hormone/metabolismFluorescent Antibody TechniqueMaleParaventricular Hypothalamic Nucleus/metabolismPituitary Gland, Anterior/secretionRatsSecretory RateVasopressins/metabolism
Identifiers
PMID: 3010303
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Structures
Research group Progéniteurs neuronaux (141)
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MEZEY, E et al. Role of cholecystokinin in corticotropin release: coexistence with vasopressin and corticotropin-releasing factor in cells of the rat hypothalamic paraventricular nucleus. In: Proceedings of the National Academy of Sciences, 1986, vol. 83, n° 10, p. 3510-2. https://archive-ouverte.unige.ch/unige:74766

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Deposited on : 2015-08-19

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