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Title

Role of cholecystokinin in corticotropin release: coexistence with vasopressin and corticotropin-releasing factor in cells of the rat hypothalamic paraventricular nucleus
Authors
Mezey, E
Reisine, T D
Skirboll, L
Beinfeld, M
Kiss, Jozsef Zoltan
Published in Proceedings of the National Academy of Sciences. 1986, vol. 83, no. 10, p. 3510-2
Abstract Cholecystokinin-8 (CCK8)-containing cell bodies in the parvocellular region of the rat paraventricular nucleus (PVN) contain vasopressin and corticotropin-releasing factor (CRF). The CCK8 and vasopressin in these cells can readily be visualized in adrenalectomized, but not in shamoperated animals. Furthermore, CCK8 levels as measured by RIA change in the PVN and in the median eminence in response to adrenalectomy. CCK8 has a stimulatory effect on corticotropin (ACTH) release from primary cultures of the anterior pituitary. This stimulation is additive with that produced by vasopressin; CCK8 plus vasopressin have an effect as great as CRF in stimulating ACTH release. Our results suggest that CCK8 may participate in the regulation of ACTH release under certain physiological conditions.
Keywords Adrenalectomy — Adrenocorticotropic Hormone/secretion — Animals — Cells, Cultured — Cholecystokinin/physiology — Corticotropin-Releasing Hormone/metabolism — Fluorescent Antibody Technique — Male — Paraventricular Hypothalamic Nucleus/metabolism — Pituitary Gland, Anterior/secretion — Rats — Secretory Rate — Vasopressins/metabolism
Identifiers
PMID: 3010303
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Article (Published version) (873 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Research group Progéniteurs neuronaux (141)
Citation
(ISO format) 		MEZEY, E et al. Role of cholecystokinin in corticotropin release: coexistence with vasopressin and corticotropin-releasing factor in cells of the rat hypothalamic paraventricular nucleus. In: Proceedings of the National Academy of Sciences of the United States of America, 1986, vol. 83, n° 10, p. 3510-2. https://archive-ouverte.unige.ch/unige:74766

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Deposited on : 2015-08-19

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