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Title

DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization

Authors
Rubio, Carlos A
Silverio, Caseiro
Published in Diagnostic Pathology. 2015, vol. 10, p. 92
Abstract Several types of colorectal cancers are associated with a prominent lymphoid component, which is considered a positive prognostic factor.We report a case of a dome-type carcinoma of the cecum in a 57 year old female.The sessile, non-polypoid lesion histologically consisted of a tubulovillous adenoma with low-grade dysplasia.The submucosal invasive component showed low-grade architectural features that included cystically dilated glands containing eosinohilic debris. Immunohistochemical studies displayed retention of the four mistmach repair proteins, consistent with a stable phenotype. After 3 years, the patient remains free of recurrence.A literature review highlighted striking similarities between dome-type carcinoma and the gut-associated lymphoid tissue carcinoma, the two sharing an intimate association with the gut associated lymphoid tissue.The two variants might therefore be grouped into a unified category.
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PMID: 26156870
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Article (Published version) (3.3 MB) - public document Free access
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Research group Métastases du foie (657)
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KANNUNA, Hala et al. DOME/GALT type adenocarcimoma of the colon: a case report, literature review and a unified phenotypic categorization. In: Diagnostic Pathology, 2015, vol. 10, p. 92. https://archive-ouverte.unige.ch/unige:74681

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Deposited on : 2015-08-12

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