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Scientific article
English

Travel and the spread of HIV-1 genetic variants

Contributors

Perrin, Luc; Kaiser, Laurent; Yerly Ferrillo, Sabine

Published in

Lancet. Infectious diseases, vol. 3, no. 1, p. 22-27

Publication date

2003

Abstract

HIV-1 comprises three groups, the main (M group), O (outlier) and N (non-M, non-O). The M group, divided into 11 subtypes, is responsible for the global HIV-1 pandemic. Recombination between M subtypes has resulted in the generation of multiple circulating recombinant forms (CRFs) consisting of mosaic lineages. Most subtypes and CRFs are represented in Africa, whereas predominance of one or a few subtypes was reported initially elsewhere. This finding reflects the African origin of the epidemic. In western countries, where the B subtype is predominant, there is a steep increase in non B-subtypes and CRFs, while new recombinants emerge worldwide. Travellers contribute to the spread of HIV-1 genetic diversity worldwide, and in the developing world migration of rural populations and civil war are additional contributing factors. The spreading of HIV-1 variants has implications for diagnostic, treatment, and vaccine development.

Keywords

  • Female
  • Genetic Variation
  • HIV Infections/epidemiology/genetics/transmission
  • HIV-1/classification/genetics/pathogenicity
  • Humans
  • Male
  • Prevalence
  • Travel

UNIGE affiliation entities

Citation (ISO format)

PERRIN, Luc, KAISER, Laurent, YERLY FERRILLO, Sabine. Travel and the spread of HIV-1 genetic variants. In: Lancet. Infectious diseases, 2003, vol. 3, n° 1, p. 22–27.

Main files (1)

Article

Identifiers

Journal ISSN

1473-3099
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Technical informations

Creation

21/06/2010 10:25:39

First validation

21/06/2010 10:25:39

Update

14/03/2023 15:44:57

Status update

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