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Title

Bone marrow transplantation as treatment for X-linked immunodeficiency with hyper-IgM.

Authors
Bordigoni, P
Auburtin, B
Carret, A S
Schuhmacher, A
Le Deist, F
Sommelet, D
Published in Bone Marrow Transplantation. 1998, vol. 22, no. 11, p. 1111-4
Abstract We report a 10-year-old boy with a severe form of immunodeficiency with hyper-IgM who underwent successful bone marrow transplantation with his HLA-matched sister as donor. Busulfan (20 mg/kg) and cyclophosphamide (200 mg/kg) were used as conditioning. The post-transplant course was uneventful. He is alive 25 months later with full hematological and immunological reconstitution.
Keywords B-Lymphocytes/immunologyBone Marrow TransplantationCD40 LigandChildChimera/geneticsFemaleGenetic LinkageHumansHypergammaglobulinemia/genetics/therapyImmunoglobulin M/bloodImmunologic Deficiency Syndromes/genetics/therapyMaleMembrane Glycoproteins/deficiency/geneticsPoint MutationT-Lymphocytes/immunologyTransplantation, HomologousX Chromosome/genetics
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PMID: 9877275
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BORDIGONI, P et al. Bone marrow transplantation as treatment for X-linked immunodeficiency with hyper-IgM. In: Bone Marrow Transplantation , 1998, vol. 22, n° 11, p. 1111-4. https://archive-ouverte.unige.ch/unige:74619

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Deposited on : 2015-08-10

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