Scientific article
Case report
Open access

Bone marrow transplantation as treatment for X-linked immunodeficiency with hyper-IgM

Published inBone marrow transplantation, vol. 22, no. 11, p. 1111-1114
Publication date1998

We report a 10-year-old boy with a severe form of immunodeficiency with hyper-IgM who underwent successful bone marrow transplantation with his HLA-matched sister as donor. Busulfan (20 mg/kg) and cyclophosphamide (200 mg/kg) were used as conditioning. The post-transplant course was uneventful. He is alive 25 months later with full hematological and immunological reconstitution.

  • B-Lymphocytes/immunology
  • Bone Marrow Transplantation
  • CD40 Ligand
  • Child
  • Chimera/genetics
  • Female
  • Genetic Linkage
  • Humans
  • Hypergammaglobulinemia/genetics/therapy
  • Immunoglobulin M/blood
  • Immunologic Deficiency Syndromes/genetics/therapy
  • Male
  • Membrane Glycoproteins/deficiency/genetics
  • Point Mutation
  • T-Lymphocytes/immunology
  • Transplantation, Homologous
  • X Chromosome/genetics
Citation (ISO format)
BORDIGONI, P et al. Bone marrow transplantation as treatment for X-linked immunodeficiency with hyper-IgM. In: Bone marrow transplantation, 1998, vol. 22, n° 11, p. 1111–1114. doi: 10.1038/sj.bmt.1701497
Main files (1)
Article (Published version)
ISSN of the journal0268-3369

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