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Chemotactic factors in bronchial secretions of cystic fibrosis patients

Published in The Journal of Infectious Diseases. 1998, vol. 177, no. 5, p. 1413-7
Abstract To understand chronic neutrophil attraction into cystic fibrosis airways, both global chemotactic activity and individual chemotactic factors were studied in bronchial secretions. Bronchial secretions of 8 cystic fibrosis patients, collected on the first day of admission for antibiotic treatment, showed a high chemotactic index (19.4 +/- 5.7, n = 8). Fractionation by gel filtration of bronchial secretions resulted in three chemotactic fractions. The first factor corresponded to interleukin-8, and the second activated neutrophils via the FMLP receptor. The third factor, which was of lower molecular weight, did not activate FMLP or leukotriene B4 receptors, and its nature is still under investigation. Treating patients with antibiotics reduced global chemotactic activity, mainly by reducing the activity due to stimulation of the FMLP receptor.
Keywords AdolescentAdultAminoglycosidesAnti-Bacterial Agents/therapeutic useBronchi/secretionBronchoalveolar Lavage Fluid/chemistryCephalosporins/therapeutic useChemotactic Factors/analysisChemotaxis, LeukocyteChildChromatography, GelCystic Fibrosis/complications/physiopathologyDrug Therapy, Combination/therapeutic useHumansMiddle AgedPseudomonas Infections/complications/drug therapySputum/chemistry
PMID: 9593037
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Research group Gastroentérologie et transplantation (pédiatrie) (181)
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DAYER, Fabienne Gabrielle et al. Chemotactic factors in bronchial secretions of cystic fibrosis patients. In: The Journal of Infectious Diseases, 1998, vol. 177, n° 5, p. 1413-7. https://archive-ouverte.unige.ch/unige:74610

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Deposited on : 2015-08-10

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