More than 60 years have passed since the work of Rosalind Franklin, James Watson, and Francis Crick led to the discovery of the 3D-DNA double-helix structure. Nowadays, due to the simple and elegant architecture of its double helix, the structure of DNA is widely known. The biological role of the DNA molecule (e.g., genetic information), however, along with the cellular mechanisms involving the DNA double helix (e.g., DNA replication) are topics that have not yet reached a broader public. In this educational article, we aim to provide a way for schoolchildren to live a three-dimensional experience that focuses on the DNA double helix structure. Moreover, taking advantage of an engaging and visual protocol, students will experience an overview of its biological implications. To do so, starting from a gene sequence, students will have the opportunity to build their own 3D-DNA double helix structure using PlayMais flakes.