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Title

Blockade of acute grade IV skin and eye graft-versus-host disease by anti-interleukin-2 receptor monoclonal antibody in genoidentical bone marrow transplantation setting

Authors
Tuchschmid, P
Lauener, R
Waldvogel, K
Nadal, D
Seger, R A
Published in Turkish Journal of Pediatrics. 1998, vol. 40, no. 2, p. 231-5
Abstract A six-year-old boy with homozygous beta-thalassemia in the favorable class 1 risk group received a bone marrow transplant, from his histocompatible sister. He developed grade IV skin and eye graft-versus-host disease (GVHD) following varicella zoster reactivation. Despite the appropriate prophylactic use of cyclosporin A (CsA), methotrexate (MTX), and prompt treatment with high-dose steroids, GVHD progressed resulting in total body epidermal necrolysis. Anti-IL-2 receptor monoclonal antibodies (anti-IL-2R moAb) in combination with steroids were administered to selectively block the activated T cells. After 27 days of daily administration, followed by 17 doses of alternate-day therapy with anti-IL-2R moAb, the severe skin and eye GVHD resolved. The patient, at two years posttransplant, has full engraftment and immune reconstitution without chronic GVHD (cGVHD). In conclusion, we suggest that in the HLA-genoidentical bone marrow transplantation setting, very severe and steroid-resistant GVHD can be controlled through the use of anti-IL-2 receptor antibodies which specifically block the activated IL-2 receptor expressing T cells.
Keywords Acute DiseaseAntibodies, Monoclonal/therapeutic useBone Marrow Transplantation/adverse effectsChildEye Diseases/etiology/therapyGraft vs Host Disease/etiology/therapyHerpes Zoster/etiologyHumansImmunosuppressive Agents/therapeutic useMaleReceptors, Interleukin-2/drug effectsRecurrenceSkin Diseases/etiology/therapyBeta-Thalassemia/therapy
Identifiers
PMID: 9677728
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OZSAHIN, Ayse Hulya et al. Blockade of acute grade IV skin and eye graft-versus-host disease by anti-interleukin-2 receptor monoclonal antibody in genoidentical bone marrow transplantation setting. In: Turkish Journal of Pediatrics, 1998, vol. 40, n° 2, p. 231-5. https://archive-ouverte.unige.ch/unige:74572

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Deposited on : 2015-08-10

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