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Title

Attenuation of ventilator-induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins (NPC 15669)
Authors
Rimensberger, Peter
Fedorko, L
Cutz, E
Bohn, D J
Published in Critical Care Medicine. 1998, vol. 26, no. 3, p. 548-55
Abstract Beta2-integrin (CD11b/CD18) expression, an indicator of neutrophil activation, has been associated with the development of acute respiratory distress syndrome. Leumedins act directly on leukocytes to inhibit the up-regulated expression of beta2-integrins involved in leukocyte adhesion. We examined the effect of such a new anti-inflammatory agent, NPC 15669 (N-[9H-(2,7-dimethylfluorenyl-9-methoxy)-carbonyl]-L-leucine), on neutrophil-mediated acute lung injury in an animal model.
Keywords Animals — Anti-Inflammatory Agents, Non-Steroidal/pharmacology — Cell Adhesion/drug effects — Immunohistochemistry — Intercellular Adhesion Molecule-1/analysis — Leucine/analogs & derivatives/pharmacology — Lung/metabolism/pathology — Lung Compliance — Neutrophils/drug effects/physiology — Oxygen/blood — Peroxidase/metabolism — Positive-Pressure Respiration — Pulmonary Gas Exchange — Rabbits — Random Allocation — Respiration, Artificial/adverse effects — Respiratory Distress Syndrome, Adult/etiology/metabolism/pathology/physiopathology — Tidal Volume
Identifiers
PMID: 9504585
Full text
Article (Published version) (4.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group Maladies pulmonaires aigues et pathologies cardiaques congénitales (697)
Citation
(ISO format) 		RIMENSBERGER, Peter et al. Attenuation of ventilator-induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins (NPC 15669). In: Critical Care Medicine, 1998, vol. 26, n° 3, p. 548-55. doi: 10.1097/00003246-199803000-00030 https://archive-ouverte.unige.ch/unige:74564

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Deposited on : 2015-08-10

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