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Attenuation of ventilator-induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins (NPC 15669) |
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Published in | Critical Care Medicine. 1998, vol. 26, no. 3, p. 548-55 | |
Abstract | Beta2-integrin (CD11b/CD18) expression, an indicator of neutrophil activation, has been associated with the development of acute respiratory distress syndrome. Leumedins act directly on leukocytes to inhibit the up-regulated expression of beta2-integrins involved in leukocyte adhesion. We examined the effect of such a new anti-inflammatory agent, NPC 15669 (N-[9H-(2,7-dimethylfluorenyl-9-methoxy)-carbonyl]-L-leucine), on neutrophil-mediated acute lung injury in an animal model. | |
Keywords | Animals — Anti-Inflammatory Agents, Non-Steroidal/pharmacology — Cell Adhesion/drug effects — Immunohistochemistry — Intercellular Adhesion Molecule-1/analysis — Leucine/analogs & derivatives/pharmacology — Lung/metabolism/pathology — Lung Compliance — Neutrophils/drug effects/physiology — Oxygen/blood — Peroxidase/metabolism — Positive-Pressure Respiration — Pulmonary Gas Exchange — Rabbits — Random Allocation — Respiration, Artificial/adverse effects — Respiratory Distress Syndrome, Adult/etiology/metabolism/pathology/physiopathology — Tidal Volume | |
Identifiers | PMID: 9504585 | |
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Research group | Maladies pulmonaires aigues et pathologies cardiaques congénitales (697) | |
Citation (ISO format) | RIMENSBERGER, Peter et al. Attenuation of ventilator-induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins (NPC 15669). In: Critical Care Medicine, 1998, vol. 26, n° 3, p. 548-55. doi: 10.1097/00003246-199803000-00030 https://archive-ouverte.unige.ch/unige:74564 |