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Title

Attenuation of ventilator-induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins (NPC 15669)

Authors
Fedorko, L
Cutz, E
Bohn, D J
Published in Critical Care Medicine. 1998, vol. 26, no. 3, p. 548-55
Abstract Beta2-integrin (CD11b/CD18) expression, an indicator of neutrophil activation, has been associated with the development of acute respiratory distress syndrome. Leumedins act directly on leukocytes to inhibit the up-regulated expression of beta2-integrins involved in leukocyte adhesion. We examined the effect of such a new anti-inflammatory agent, NPC 15669 (N-[9H-(2,7-dimethylfluorenyl-9-methoxy)-carbonyl]-L-leucine), on neutrophil-mediated acute lung injury in an animal model.
Keywords AnimalsAnti-Inflammatory Agents, Non-Steroidal/pharmacologyCell Adhesion/drug effectsImmunohistochemistryIntercellular Adhesion Molecule-1/analysisLeucine/analogs & derivatives/pharmacologyLung/metabolism/pathologyLung ComplianceNeutrophils/drug effects/physiologyOxygen/bloodPeroxidase/metabolismPositive-Pressure RespirationPulmonary Gas ExchangeRabbitsRandom AllocationRespiration, Artificial/adverse effectsRespiratory Distress Syndrome, Adult/etiology/metabolism/pathology/physiopathologyTidal Volume
Identifiers
PMID: 9504585
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Article (Published version) (4.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Maladies pulmonaires aigues et pathologies cardiaques congénitales (697)
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RIMENSBERGER, Peter et al. Attenuation of ventilator-induced acute lung injury in an animal model by inhibition of neutrophil adhesion by leumedins (NPC 15669). In: Critical Care Medicine, 1998, vol. 26, n° 3, p. 548-55. https://archive-ouverte.unige.ch/unige:74564

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Deposited on : 2015-08-10

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