UNIGE document Scientific Article
previous document  unige:74563  next document
add to browser collection

Toxoplasma gondii Hsp90: potential roles in essential cellular processes of the parasite

Angel, Sergio O
Figueras, Maria J
Alomar, Maria L
Deng, Bin
Published in Parasitology. 2014, vol. 141, no. 9, p. 1138-1147
Abstract Hsp90 is a widely distributed and highly conserved molecular chaperone that is ubiquitously expressed throughout nature, being one of the most abundant proteins within non-stressed cells. This chaperone is up-regulated following stressful events and has been involved in many cellular processes. In Toxoplasma gondii, Hsp90 could be linked with many essential processes of the parasite such as host cell invasion, replication and tachyzoite-bradyzoite interconversion. A Protein-Protein Interaction (PPI) network approach of TgHsp90 has allowed inferring how these processes may be altered. In addition, data mining of T. gondii phosphoproteome and acetylome has allowed the generation of the phosphorylation and acetylation map of TgHsp90. This review focuses on the potential roles of TgHsp90 in parasite biology and the analysis of experimental data in comparison with its counterparts in yeast and humans.
Keywords Cell CycleGene Expression Regulation/physiologyHSP90 Heat-Shock Proteins/genetics/metabolismProtein ProcessingPost-TranslationalProtozoan Proteins/genetics/metabolismToxoplasma/cytology/genetics/metabolism
PMID: 24560345
Full text
Article (Published version) (248 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Groupe Picard
(ISO format)
ANGEL, Sergio O et al. Toxoplasma gondii Hsp90: potential roles in essential cellular processes of the parasite. In: Parasitology, 2014, vol. 141, n° 9, p. 1138-1147. doi: 10.1017/S0031182014000055 https://archive-ouverte.unige.ch/unige:74563

421 hits

0 download


Deposited on : 2015-08-10

Export document
Format :
Citation style :