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Non-invasive epileptic focus localization using EEG-triggered functional MRI and electromagnetic tomography

Gericke, CA
Ives, J
Golay, X
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Published in Electroencephalography and clinical neurophysiology. 1998, vol. 106, no. 6, p. 508-12
Abstract We present a new approach for non-invasive localization of focal epileptogenic discharges in patients considered for surgical treatment. EEG-triggered functional MR imaging (fMRI) and 3D EEG source localization were combined to map the primary electrical source with high spatial resolution. The method is illustrated by the case of a patient with medically intractable frontal lobe epilepsy. EEG obtained in the MRI system allowed triggering of the fMRI acquisition by the patient's habitual epileptogenic discharges. fMRI revealed multiple areas of signal enhancement. Three-dimensional EEG source localization identified the same active areas and provided evidence of onset in the left frontal lobe. Subsequent electrocorticography from subdural electrodes confirmed spike and seizure onset over this region. This approach, i.e. the combination of EEG-triggered fMRI and 3D EEG source analysis, represents a promising additional tool for presurgical epilepsy evaluation allowing precise non-invasive identification of the epileptic foci.
Keywords AdolescentElectroencephalography/methodsEpilepsies, Partial/physiopathologyEpilepsy, Frontal Lobe/physiopathologyFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance Imaging/methodsMagnetoencephalography/methodsTomography
PMID: 9741750
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Research groups Epilepsie et Chirurgie (149)
Organisation et plasticité des réseaux neuronaux cérébraux (148)
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SEECK, Margitta et al. Non-invasive epileptic focus localization using EEG-triggered functional MRI and electromagnetic tomography. In: Electroencephalography and clinical neurophysiology, 1998, vol. 106, n° 6, p. 508-12. doi: 10.1016/s0013-4694(98)00017-0 https://archive-ouverte.unige.ch/unige:74560

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