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Diagnostic performance of line-immunoassay based algorithms for incident HIV-1 infection

Schüpbach, Jörg
Bisset, Leslie R
Gebhardt, Martin D
Regenass, Stephan
Bürgisser, Philippe
Gorgievski, Meri
Klimkait, Thomas
Andreutti, Corinne
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Published in BMC infectious diseases. 2012, vol. 12, 88
Abstract Serologic testing algorithms for recent HIV seroconversion (STARHS) provide important information for HIV surveillance. We have previously demonstrated that a patient's antibody reaction pattern in a confirmatory line immunoassay (INNO-LIA™ HIV I/II Score) provides information on the duration of infection, which is unaffected by clinical, immunological and viral variables. In this report we have set out to determine the diagnostic performance of Inno-Lia algorithms for identifying incident infections in patients with known duration of infection and evaluated the algorithms in annual cohorts of HIV notifications.
Keywords AdultAlgorithmsClinical Laboratory Techniques/methodsFemaleHIV Antibodies/bloodHIV Infections/diagnosis/virologyHIV-1/immunology/isolation & purificationHumansImmunoassay/methodsMaleMiddle AgedPlasma/immunologySensitivity and SpecificityVirology/methods
PMID: 22497961
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Research group Groupe Laurent Kaiser (virologie clinique) (668)
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SCHÜPBACH, Jörg et al. Diagnostic performance of line-immunoassay based algorithms for incident HIV-1 infection. In: BMC Infectious Diseases, 2012, vol. 12, p. 88. doi: 10.1186/1471-2334-12-88 https://archive-ouverte.unige.ch/unige:74518

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Deposited on : 2015-08-06

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