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Scientific article
Open access
English

Translationally controlled tumour protein (TCTP) is present in human cornea and increases in herpetic keratitis

Published inDiagnostic pathology, vol. 7, 90
Publication date2012
Abstract

Translationally controlled tumour protein is a multifunctional calcium binding protein which has an important role in apoptosis, calcium levels balance and immunological response. The aim of this study was to evaluated the presence and distribution of TCTP in healthy human corneas and to identify and characterize the presence and distribution of this protein in human normal cornea. Since recent studies suggest that apoptosis, calcium levels and immunological mechanisms play a role in the pathogenesis of herpetic stromal keratitis, we studied TCTP expression in this disease.

Keywords
  • Blotting, Western
  • Case-Control Studies
  • Cornea/chemistry/pathology/virology
  • Humans
  • Immunohistochemistry
  • Keratitis, Herpetic/genetics/metabolism/pathology/virology
  • Molecular Weight
  • Paraffin Embedding
  • RNA, Messenger/analysis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tumor Markers, Biological/analysis/chemistry/genetics
  • Up-Regulation
Citation (ISO format)
BATISTI, Cinzia et al. Translationally controlled tumour protein (TCTP) is present in human cornea and increases in herpetic keratitis. In: Diagnostic pathology, 2012, vol. 7, p. 90. doi: 10.1186/1746-1596-7-90
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Article (Published version)
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ISSN of the journal1746-1596
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