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Title

Translationally controlled tumour protein (TCTP) is present in human cornea and increases in herpetic keratitis

Authors
Batisti, Cinzia
Ambrosio, Maria R
Rocca, Bruno J
Tosi, Gian M
Sanchez, Jean Charles
Arcuri, Felice
Cintorino, Marcella
Tripodi, Sergio A
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Published in Diagnostic Pathology. 2012, vol. 7, p. 90
Abstract Translationally controlled tumour protein is a multifunctional calcium binding protein which has an important role in apoptosis, calcium levels balance and immunological response. The aim of this study was to evaluated the presence and distribution of TCTP in healthy human corneas and to identify and characterize the presence and distribution of this protein in human normal cornea. Since recent studies suggest that apoptosis, calcium levels and immunological mechanisms play a role in the pathogenesis of herpetic stromal keratitis, we studied TCTP expression in this disease.
Keywords Blotting, WesternCase-Control StudiesCornea/chemistry/pathology/virologyHumansImmunohistochemistryKeratitis, Herpetic/genetics/metabolism/pathology/virologyMolecular WeightParaffin EmbeddingRNA, Messenger/analysisReverse Transcriptase Polymerase Chain ReactionTumor Markers, Biological/analysis/chemistry/geneticsUp-Regulation
Identifiers
PMID: 22853445
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Article (Published version) (2.5 MB) - public document Free access
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Research group Groupe de Protéomique biomédicale (635)
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BATISTI, Cinzia et al. Translationally controlled tumour protein (TCTP) is present in human cornea and increases in herpetic keratitis. In: Diagnostic Pathology, 2012, vol. 7, p. 90. https://archive-ouverte.unige.ch/unige:74517

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Deposited on : 2015-08-06

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