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HDL protects against ischemia reperfusion injury by preserving mitochondrial integrity

Hacking, Damian
Somers, Sarin
Lacerda, Lydia
Opie, Lionel H
Lecour, Sandrine
Published in Atherosclerosis. 2013, vol. 228, no. 1, p. 110-6
Abstract High density lipoproteins (HDL) protect against ischemia reperfusion injury (IRI). However the precise mechanisms are not clearly understood. The novel intrinsic prosurvival signaling pathway named survivor activating factor enhancement (SAFE) path involves the activation of tumor necrosis factor (TNF) alpha and signal transducer and activator of transcription 3 (STAT3). SAFE plays a crucial role in cardioprotection against IRI. We propose that HDL protect against IRI via activation of the SAFE pathway and modulation of the mitochondrial permeability transition pore (mPTP) opening.
Keywords AnimalsCell Survival/physiologyCholesterol, HDL/metabolismMiceMice, Inbred C57BLMice, KnockoutMitochondria/metabolismMitochondrial Membranes/metabolismMyocardial Infarction/metabolism/pathologyMyocardial Reperfusion Injury/metabolism/pathologyMyocytes, Cardiac/metabolism/pathologyPhosphorylation/physiologySTAT3 Transcription Factor/geneticsSignal Transduction/physiologyTumor Necrosis Factor-alpha/genetics
PMID: 23497785
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Research group Lipoprotéines sériques (598)
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FRIAS, Miguel et al. HDL protects against ischemia reperfusion injury by preserving mitochondrial integrity. In: Atherosclerosis, 2013, vol. 228, n° 1, p. 110-6. doi: 10.1016/j.atherosclerosis.2013.02.003 https://archive-ouverte.unige.ch/unige:74516

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Deposited on : 2015-08-06

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