Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children

Cangiano, Giulia; Proietti, Elena; Kronig, Marie Noelle; Kieninger, Elisabeth; Sadeghi, Christine D; Gorgievski, Meri; Barbani, Maria Teresa; Midulla, Fabio; Tapparel, Caroline; Kaiser, Laurent; Alves, Marco P; Regamey, Nicolas

doi:10.1097/INF.0000000000000420

Scientific article

English

Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children

ContributorsCangiano, Giulia; Proietti, Elena; Kronig, Marie Noelle; Kieninger, Elisabeth; Sadeghi, Christine D; Gorgievski, Meri; Barbani, Maria Teresa; Midulla, Fabio; Tapparel, Caroline

; Kaiser, Laurent; Alves, Marco P; Regamey, Nicolas

Published inThe Pediatric infectious disease journal, vol. 33, no. 12, p. 1285-1287

Publication date2014

Abstract

The clinical course of rhinovirus (RV)-associated wheezing illnesses is difficult to predict. We measured lactate dehydrogenase concentrations, RV load, antiviral and proinflammatory cytokines in nasal washes obtained from 126 preschool children with RV wheezy bronchitis. lactate dehydrogenase values were inversely associated with subsequent need for oxygen therapy. lactate dehydrogenase may be a useful biomarker predicting disease severity in RV wheezy bronchitis.

Keywords

Biological Markers/analysis
Bronchitis/diagnosis/pathology
Child, Preschool
Cytokines/analysis
Female
Humans
Infant
L-Lactate Dehydrogenase/analysis
Male
Nasal Mucosa/chemistry
Picornaviridae Infections/diagnosis/pathology
Retrospective Studies
Rhinovirus/isolation & purification
Severity of Illness Index
Viral Load

Affiliation

Research group

Citation (ISO format)

CANGIANO, Giulia et al. Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children. In: The Pediatric infectious disease journal, 2014, vol. 33, n° 12, p. 1285–1287. doi: 10.1097/INF.0000000000000420

Article (Published version)

Identifiers

PID : unige:74426
DOI : 10.1097/INF.0000000000000420
PMID : 25389710

ISSN of the journal0891-3668

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Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children

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