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Title

Epidemiology of viral respiratory infections in a tertiary care centre in the era of molecular diagnosis, Geneva, Switzerland, 2011-2012
Authors
Ambrosioni Czyrko, Juan
Bridevaux, Pierre-Olivier
Wagner-killy, Germaine
Mamin, Aline
Kaiser, Laurent
Published in Clinical Microbiology and Infection. 2014, vol. 20, no. 9, p. O578-84
Abstract Few studies have examined the epidemiology of respiratory viral infections in large tertiary centres over more than one season in the era of molecular diagnosis. Respiratory clinical specimens received between 1 January 2011 and 31 December 2012 were analysed. Respiratory virus testing was performed using a large panel of real-time PCR or RT-PCR. Results were analysed according to sample type (upper versus lower respiratory tract) and age group. In all, 2996 (2469 (82.4%) upper; 527 (17.6%) lower) specimens were analysed. Overall positivity rate was 47.4% and 23.7% for upper and lower respiratory samples, respectively. The highest positivity rate was observed in patients under 18 years old (p <0.001); picornaviruses were the most frequent viruses detected over the year. Influenza virus, respiratory syncytial virus, human metapneumovirus and coronaviruses showed a seasonal peak during the winter season, while picornaviruses and adenoviruses were less frequently detected in these periods. Multiple viral infections were identified in 12% of positive cases and were significantly more frequent in children (p <0.001). In conclusion, we observed significant differences in viral infection rates and virus types among age groups, clinical sample types and seasons. Follow-up of viral detection over several seasons allows a better understanding of respiratory viral epidemiology.
Keywords Adolescent — Adult — Aged — Aged, 80 and over — Child — Child, Preschool — Coinfection/epidemiology/virology — Female — Humans — Infant — Infant, Newborn — Male — Middle Aged — Molecular Diagnostic Techniques — Prevalence — Real-Time Polymerase Chain Reaction — Respiratory Tract Infections/epidemiology/virology — Reverse Transcriptase Polymerase Chain Reaction — Switzerland/epidemiology — Tertiary Care Centers — Virus Diseases/epidemiology/virology — Viruses/classification/genetics/isolation & purification — Young Adult
Identifiers
PMID: 24382326
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Article (Published version) (657 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Research group Groupe Laurent Kaiser (virologie clinique) (668)
Citation
(ISO format) 		AMBROSIONI CZYRKO, Juan et al. Epidemiology of viral respiratory infections in a tertiary care centre in the era of molecular diagnosis, Geneva, Switzerland, 2011-2012. In: Clinical Microbiology and Infection, 2014, vol. 20, n° 9, p. O578-84. doi: 10.1111/1469-0691.12525 https://archive-ouverte.unige.ch/unige:74424

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Deposited on : 2015-07-29

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