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Title

Co-trimoxazole prophylaxis is associated with reduced risk of incident tuberculosis in participants in the Swiss HIV Cohort Study

Authors
Hasse, Barbara
Walker, A Sarah
Fehr, Jan
Furrer, Hansjakob
Hoffmann, Matthias
Battegay, Manuel
Fellay, Jacques
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Published in Antimicrobial Agents and Chemotherapy. 2014, vol. 58, no. 4, p. 2363-8
Abstract Co-trimoxazole reduces mortality in HIV-infected adults with tuberculosis (TB), and in vitro data suggest potential antimycobacterial activity of co-trimoxazole. We aimed to evaluate whether prophylaxis with co-trimoxazole is associated with a decreased risk of incident TB in Swiss HIV Cohort Study (SHCS) participants. We determined the incidence of TB per 1,000 person-years from January 1992 to December 2012. Rates were analyzed separately in participants with current or no previous antiretroviral treatment (ART) using Poisson regression adjusted for CD4 cell count, sex, region of origin, injection drug use, and age. A total of 13,431 cohort participants contributed 107,549 person-years of follow-up: 182 patients had incident TB-132 (73%) before and 50 (27%) after ART initiation. The multivariable incidence rate ratios for cumulative co-trimoxazole exposure per year for persons with no previous ART and current ART were 0.70 (95% confidence interval [CI], 0.55 to 0.89) and 0.87 (95% CI, 0.74 to 1.0), respectively. Co-trimoxazole may prevent the development of TB among HIV-positive persons, especially among those with no previous ART.
Keywords AdultAnti-Retroviral Agents/therapeutic useCoinfection/prevention & controlFemaleHIV Infections/drug therapyHumansMaleProspective StudiesTrimethoprim-Sulfamethoxazole Combination/therapeutic useTuberculosis/prevention & control
Identifiers
PMID: 24514096
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Research group VIH/SIDA (930)
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HASSE, Barbara et al. Co-trimoxazole prophylaxis is associated with reduced risk of incident tuberculosis in participants in the Swiss HIV Cohort Study. In: Antimicrobial Agents and Chemotherapy, 2014, vol. 58, n° 4, p. 2363-8. https://archive-ouverte.unige.ch/unige:74404

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Deposited on : 2015-07-29

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