en
Scientific article
English

Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients

Published inAIDS, vol. 28, no. 15, p. 2231-2239
Publication date2014
Abstract

The presence of minority nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 variants prior to antiretroviral therapy (ART) has been linked to virologic failure in treatment-naive patients.

Keywords
  • Adult
  • Alleles
  • Anti-Retroviral Agents/therapeutic use
  • Drug Resistance, Viral
  • Female
  • Genotyping Techniques/methods
  • HIV Infections/virology
  • HIV Reverse Transcriptase/genetics
  • HIV-1/enzymology/genetics/isolation & purification
  • Humans
  • Male
  • Microbial Sensitivity Tests/methods
  • Middle Aged
  • Mutation, Missense
  • Retrospective Studies
  • Treatment Outcome
Citation (ISO format)
METZNER, Karin J et al. Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients. In: AIDS, 2014, vol. 28, n° 15, p. 2231–2239. doi: 10.1097/QAD.0000000000000397
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0269-9370
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