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Title

Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients

Authors
Metzner, Karin J
Scherrer, Alexandra U
von Wyl, Viktor
Böni, Jürg
Klimkait, Thomas
Furrer, Hansjakob
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Published in AIDS. 2014, vol. 28, no. 15, p. 2231-9
Abstract The presence of minority nonnucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 variants prior to antiretroviral therapy (ART) has been linked to virologic failure in treatment-naive patients.
Keywords AdultAllelesAnti-Retroviral Agents/therapeutic useDrug Resistance, ViralFemaleGenotyping Techniques/methodsHIV Infections/virologyHIV Reverse Transcriptase/geneticsHIV-1/enzymology/genetics/isolation & purificationHumansMaleMicrobial Sensitivity Tests/methodsMiddle AgedMutation, MissenseRetrospective StudiesTreatment Outcome
Identifiers
PMID: 25036184
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Structures
Research groups VIH/SIDA (930)
Groupe Laurent Kaiser (virologie clinique) (668)
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(ISO format)
METZNER, Karin J et al. Limited clinical benefit of minority K103N and Y181C-variant detection in addition to routine genotypic resistance testing in antiretroviral therapy-naive patients. In: AIDS, 2014, vol. 28, n° 15, p. 2231-9. https://archive-ouverte.unige.ch/unige:74401

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Deposited on : 2015-07-29

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