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Scientific article
Meta-analysis
English

Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis

ContributorsFord, Nathan; Mofenson, Lynne; Shubber, Zara; Calmy, Alexandraorcid; Andrieux-Meyer, Isabelle; Vitoria, Marco; Shaffer, Nathan; Renaud, Françoise
Published inAIDS, vol. 28 Suppl 2, p. S123-131
Publication date2014
Abstract

Primate studies and some observational human data have raised concern regarding an association of first-trimester efavirenz exposure with central nervous system congenital anomalies. The objective of this review is to update evidence on efavirenz safety in HIV-infected pregnant women to inform revision of the 2013 WHO guidelines for antiretroviral therapy in low and middle-income countries.

Keywords
  • Abnormalities, Drug-Induced/epidemiology
  • Benzoxazines/adverse effects
  • Central Nervous System Diseases/chemically induced/congenital
  • Female
  • HIV Infections/drug therapy
  • Humans
  • Infectious Disease Transmission, Vertical/prevention & control
  • Pregnancy
  • Pregnancy Complications, Infectious/drug therapy
  • Pregnancy Trimester, First
  • Reverse Transcriptase Inhibitors/adverse effects
  • Treatment Outcome
Affiliation entities
Research groups
Citation (ISO format)
FORD, Nathan et al. Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis. In: AIDS, 2014, vol. 28 Suppl 2, p. S123–131. doi: 10.1097/QAD.0000000000000231
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0269-9370
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Technical informations

Creation09/07/2015 14:31:00
First validation09/07/2015 14:31:00
Update14/03/2023 23:30:34
Status update14/03/2023 23:30:33
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