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Title

Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis

Authors
Ford, Nathan
Mofenson, Lynne
Shubber, Zara
Andrieux-Meyer, Isabelle
Vitoria, Marco
Shaffer, Nathan
Renaud, Françoise
Published in AIDS. 2014, vol. 28 Suppl 2, p. S123-31
Abstract Primate studies and some observational human data have raised concern regarding an association of first-trimester efavirenz exposure with central nervous system congenital anomalies. The objective of this review is to update evidence on efavirenz safety in HIV-infected pregnant women to inform revision of the 2013 WHO guidelines for antiretroviral therapy in low and middle-income countries.
Keywords Abnormalities, Drug-Induced/epidemiologyBenzoxazines/adverse effectsCentral Nervous System Diseases/chemically induced/congenitalFemaleHIV Infections/drug therapyHumansInfectious Disease Transmission, Vertical/prevention & controlPregnancyPregnancy Complications, Infectious/drug therapyPregnancy Trimester, FirstReverse Transcriptase Inhibitors/adverse effectsTreatment Outcome
Identifiers
PMID: 24849471
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Article (Published version) (340 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group VIH/SIDA (930)
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FORD, Nathan et al. Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis. In: AIDS, 2014, vol. 28 Suppl 2, p. S123-31. https://archive-ouverte.unige.ch/unige:74400

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Deposited on : 2015-07-29

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