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Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue

Published inPloS one, vol. 10, no. 5, e0126364
Publication date2015
Abstract

Beside its beneficial effects on weight loss, ketogenic diet (KD) causes dyslipidemia, a pro-inflammatory state involved in the development of hepatic steatosis, glucose intolerance and insulin resistance, although the latter is still being debated. Additionally, KD is known to increase fibroblast growth factor 21 (FGF21) plasma levels. However, FGF21 cannot initiate its beneficial actions on metabolism in these conditions. We therefore hypothesized and tested in the present study that KD may impair FGF21 signaling.

Citation (ISO format)
ASRIH, Mohamed et al. Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue. In: PloS one, 2015, vol. 10, n° 5, p. e0126364. doi: 10.1371/journal.pone.0126364
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ISSN of the journal1932-6203
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Creation07/09/2015 2:23:00 PM
First validation07/09/2015 2:23:00 PM
Update time03/14/2023 11:30:30 PM
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