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Title

Lung recruitment during small tidal volume ventilation allows minimal positive end-expiratory pressure without augmenting lung injury

Authors
Pristine, G
Mullen, B M
Cox, P N
Slutsky, A S
Published in Critical Care Medicine. 1999, vol. 27, no. 9, p. 1940-5
Abstract Ventilation with positive end-expiratory pressure (PEEP) above the inflection point (P(inf)) has been shown to reduce lung injury by recruiting previously closed alveolar regions; however, it carries the risk of hyperinflating the lungs. The present study examined the hypothesis that a new strategy of recruiting the lung with a sustained inflation (SI), followed by ventilation with small tidal volumes, would allow the maintenance of low PEEP levels (<P(inf)) without inducing additional lung injury.
Keywords Analysis of VarianceAnimalsInsufflationIntermittent Positive-Pressure Ventilation/methodsLung CompliancePositive-Pressure RespirationProspective StudiesRandom AllocationRatsRats, Sprague-DawleyRespiratory Distress Syndrome, Adult/pathology/therapyRespiratory MechanicsTotal Lung Capacity
Identifiers
PMID: 10507622
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Article (Published version) (2.5 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Maladies pulmonaires aigues et pathologies cardiaques congénitales (697)
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(ISO format)
RIMENSBERGER, Peter et al. Lung recruitment during small tidal volume ventilation allows minimal positive end-expiratory pressure without augmenting lung injury. In: Critical Care Medicine, 1999, vol. 27, n° 9, p. 1940-5. https://archive-ouverte.unige.ch/unige:74364

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Deposited on : 2015-07-27

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