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Scientific article
English

Genetic polymorphism of CCR5 gene and HIV disease: the heterozygous (CCR5/delta ccr5) genotype is neither essential nor sufficient for protection against disease progression. Swiss HIV Cohort

Contributors

Morawetz, R. A.; Rizzardi, G. P.; Glauser, Dominique; Rutschmann, Olivier Thierry; Hirschel, Bernard; Perrin, Luc; Opravil, M.; Flepp, Markus; von Overbeck, J.; Glauser, M. P.; Ghezzi, S.; Vicenzi, E.; Poli, G.; Lazzarin, A.; Pantaleo, G.

Published in

European Journal of Immunology, vol. 27, no. 12, p. 3223-3227

Publication date

1997

Abstract

Homozygous (delta ccr5/delta ccr5) and heterozygous (CCR5/delta ccr5) deletions in the beta-chemokine receptor 5 (CCR5) gene, which encodes for the major co-receptor for macrophage-tropic HIV-1 entry, have been implicated in resistance to HIV infection and in protection against disease progression, respectively. The CCR5/delta ccr5 genotype was found more frequently in long-term nonprogressors (LTNP) (31.0%) than in progressors (10.6%, p < 0.0001), in agreement with previous studies. Kaplan-Meier survival analyses showed that a slower progression of disease, i.e. higher proportion of subjects with CD4+ T cell counts > 500/microl (p = 0.0006) and a trend toward a slower progression to AIDS (p = 0.077), was associated with the CCR5/delta ccr5 genotype. However, when LTNP were analyzed separately, no significant differences in CD4+ T cell counts (p = 0.12) and viremia levels (p = 0.65) were observed between the wild-type (69% of LTNP) and the heterozygous (31.0%) genotypes. Therefore, there are other factors which play a major role in determining the status of nonprogression in the majority of LTNP. Furthermore, there was no evidence that the CCR5/delta ccr5 genotype was associated with different rates of disease progression in the group of progressors. Taken together, these results indicate that the CCR5/delta ccr5 genotype is neither essential nor sufficient for protection against the progression of HIV disease.

Keywords

  • HIV Infections/ genetics/immunology/physiopathology
  • Hiv-1
  • Heterozygote
  • Humans
  • Polymorphism, Genetic
  • Prognosis
  • Receptors, CCR5/ genetics/immunology

UNIGE affiliation entities

Citation (ISO format)

MORAWETZ, R. A. et al. Genetic polymorphism of CCR5 gene and HIV disease: the heterozygous (CCR5/delta ccr5) genotype is neither essential nor sufficient for protection against disease progression. Swiss HIV Cohort. In: European Journal of Immunology, 1997, vol. 27, n° 12, p. 3223–3227. doi: 10.1002/eji.1830271220

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Article

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Journal ISSN

0014-2980
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Technical informations

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21/06/2010 10:25:28

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