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Long-term continuous-flow left ventricular assist devices (LVAD) as bridge to heart transplantation

Pozzi, Matteo
Tozzi, Piergiorgio
Robin, Jacques
Obadia, Jean François
Published in Journal of Thoracic Disease. 2015, vol. 7, no. 3, p. 532-42
Abstract Heart transplantation (HTx) is the treatment of choice for end-stage heart failure but the limited availability of heart's donors still represents a major issue. So long-term mechanical circulatory support (MCS) has been proposed as an alternative treatment option to assist patients scheduled on HTx waiting list bridging them for a variable time period to cardiac transplantation-the so-called bridge-to-transplantation (BTT) strategy. Nowadays approximately 90% of patients being considered for MCS receive a left ventricular assist device (LVAD). In fact, LVAD experienced several improvements in the last decade and the predominance of continuous-flow over pulsatile-flow technology has been evident since 2008. The aim of the present report is to give an overview of continuous-flow LVAD utilization in the specific setting of the BTT strategy taking into consideration the most representative articles of the scientific literature and focusing the attention on the evolution, clinical outcomes, relevant implications on the HTx strategy and future perspectives of the continuous-flow LVAD technology.
PMID: 25922736
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Article (Published version) (201 Kb) - public document Free access
Research groups Groupe de Recherche en Hémodynamique (913)
Chirurgie cardio-vasculaire (105)
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POZZI, Matteo et al. Long-term continuous-flow left ventricular assist devices (LVAD) as bridge to heart transplantation. In: Journal of Thoracic Disease, 2015, vol. 7, n° 3, p. 532-42. https://archive-ouverte.unige.ch/unige:74343

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Deposited on : 2015-07-27

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