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Title

Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants
Authors
Aspesberro, François Pierre
Beghetti, Maurice
Oberhansli, Ingrid
Ozsahin, Ayse Hulya
Humbert, James Ronald
Rimensberger, Peter
Published in European Journal of Pediatrics. 1999, vol. 158, no. 9, p. 698-701
Abstract We report three cases of intracardiac thrombi in preterm infants of very low birth weight, in whom local low-dose urokinase treatment achieved complete thrombolysis without any signs of systemic fibrinolytic activity or side-effects. This new treatment strategy seems to be safe, requires minimal monitoring of fibrinolytic activity, and may be a new option for thrombolysis in high-risk patients such as premature infants, patients recently operated on, and patients presenting with other contra-indications for systemic fibrinolytic therapy.
Keywords Female — Heart Atria/ultrasonography — Heart Diseases/drug therapy — Humans — Infant, Newborn — Infant, Premature — Infant, Premature, Diseases/drug therapy — Infant, Very Low Birth Weight — Male — Plasminogen Activators/administration & dosage/therapeutic use — Risk Factors — Thrombolytic Therapy/methods — Thrombosis/drug therapy — Treatment Outcome — Urokinase-Type Plasminogen Activator/administration & dosage/therapeutic use
Identifiers
PMID: 10485298
Full text
Article (Published version) (138 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de pédiatrie
Research groups L'hypertension pulmonaire (pédiatrie) (228)
Maladies pulmonaires aigues et pathologies cardiaques congénitales (697)
Citation
(ISO format) 		ASPESBERRO, François Pierre et al. Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants. In: European Journal of Pediatrics, 1999, vol. 158, n° 9, p. 698-701. https://archive-ouverte.unige.ch/unige:74302

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Deposited on : 2015-07-27

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