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Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants |
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Published in | European Journal of Pediatrics. 1999, vol. 158, no. 9, p. 698-701 | |
Abstract | We report three cases of intracardiac thrombi in preterm infants of very low birth weight, in whom local low-dose urokinase treatment achieved complete thrombolysis without any signs of systemic fibrinolytic activity or side-effects. This new treatment strategy seems to be safe, requires minimal monitoring of fibrinolytic activity, and may be a new option for thrombolysis in high-risk patients such as premature infants, patients recently operated on, and patients presenting with other contra-indications for systemic fibrinolytic therapy. | |
Keywords | Female — Heart Atria/ultrasonography — Heart Diseases/drug therapy — Humans — Infant, Newborn — Infant, Premature — Infant, Premature, Diseases/drug therapy — Infant, Very Low Birth Weight — Male — Plasminogen Activators/administration & dosage/therapeutic use — Risk Factors — Thrombolytic Therapy/methods — Thrombosis/drug therapy — Treatment Outcome — Urokinase-Type Plasminogen Activator/administration & dosage/therapeutic use | |
Identifiers | PMID: 10485298 | |
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Research groups | L'hypertension pulmonaire (pédiatrie) (228) Maladies pulmonaires aigues et pathologies cardiaques congénitales (697) | |
Citation (ISO format) | ASPESBERRO, François Pierre et al. Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants. In: European Journal of Pediatrics, 1999, vol. 158, n° 9, p. 698-701. doi: 10.1007/s004310051182 https://archive-ouverte.unige.ch/unige:74302 |