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Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants

Published in European Journal of Pediatrics. 1999, vol. 158, no. 9, p. 698-701
Abstract We report three cases of intracardiac thrombi in preterm infants of very low birth weight, in whom local low-dose urokinase treatment achieved complete thrombolysis without any signs of systemic fibrinolytic activity or side-effects. This new treatment strategy seems to be safe, requires minimal monitoring of fibrinolytic activity, and may be a new option for thrombolysis in high-risk patients such as premature infants, patients recently operated on, and patients presenting with other contra-indications for systemic fibrinolytic therapy.
Keywords FemaleHeart Atria/ultrasonographyHeart Diseases/drug therapyHumansInfant, NewbornInfant, PrematureInfant, Premature, Diseases/drug therapyInfant, Very Low Birth WeightMalePlasminogen Activators/administration & dosage/therapeutic useRisk FactorsThrombolytic Therapy/methodsThrombosis/drug therapyTreatment OutcomeUrokinase-Type Plasminogen Activator/administration & dosage/therapeutic use
PMID: 10485298
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Research groups L'hypertension pulmonaire (pédiatrie) (228)
Maladies pulmonaires aigues et pathologies cardiaques congénitales (697)
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ASPESBERRO, François Pierre et al. Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants. In: European Journal of Pediatrics, 1999, vol. 158, n° 9, p. 698-701. doi: 10.1007/s004310051182 https://archive-ouverte.unige.ch/unige:74302

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Deposited on : 2015-07-27

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