Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants

Aspesberro, François Pierre; Beghetti, Maurice; Oberhansli, Ingrid; Ozsahin, Ayse Hulya; Humbert, James Ronald; Rimensberger, Peter

doi:10.1007/s004310051182

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Title		Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants
Authors		Aspesberro, François Pierre Beghetti, Maurice Oberhansli, Ingrid Ozsahin, Ayse Hulya Humbert, James Ronald Rimensberger, Peter
Published in		European Journal of Pediatrics. 1999, vol. 158, no. 9, p. 698-701
Abstract		We report three cases of intracardiac thrombi in preterm infants of very low birth weight, in whom local low-dose urokinase treatment achieved complete thrombolysis without any signs of systemic fibrinolytic activity or side-effects. This new treatment strategy seems to be safe, requires minimal monitoring of fibrinolytic activity, and may be a new option for thrombolysis in high-risk patients such as premature infants, patients recently operated on, and patients presenting with other contra-indications for systemic fibrinolytic therapy.
Keywords		Female — Heart Atria/ultrasonography — Heart Diseases/drug therapy — Humans — Infant, Newborn — Infant, Premature — Infant, Premature, Diseases/drug therapy — Infant, Very Low Birth Weight — Male — Plasminogen Activators/administration & dosage/therapeutic use — Risk Factors — Thrombolytic Therapy/methods — Thrombosis/drug therapy — Treatment Outcome — Urokinase-Type Plasminogen Activator/administration & dosage/therapeutic use
Identifiers		DOI: 10.1007/s004310051182 PMID: 10485298
Full text		Article (Published version) (138 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research groups		L'hypertension pulmonaire (pédiatrie) (228) Maladies pulmonaires aigues et pathologies cardiaques congénitales (697)
Citation (ISO format)		ASPESBERRO, François Pierre et al. Local low-dose urokinase treatment of acquired intracardiac thrombi in preterm infants. In: European Journal of Pediatrics, 1999, vol. 158, n° 9, p. 698-701. doi: 10.1007/s004310051182 https://archive-ouverte.unige.ch/unige:74302