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Auger radiation targeted into DNA: a therapy perspective

Perillo-Adamer, Florence
Bischof Delaloye, Angelika
Published in European Journal of Nuclear Medicine and Molecular Imaging. 2006, vol. 33, no. 11, p. 1352-1363
Abstract Abstract. Background: Auger electron emitters that can be targeted into DNA of tumour cells represent an attractive systemic radiation therapy goal. In the situation of DNA-associated decay, the high linear energy transfer (LET) of Auger electrons gives a high relative biological efficacy similar to that of α particles. In contrast to α radiation, however, Auger radiation is of low toxicity when decaying outside the cell nucleus, as in cytoplasm or outside cells during blood transport. The challenge for such therapies is the requirement to target a high percentage of all cancer cells. An overview of Auger radiation therapy approaches of the past decade shows several research directions and various targeting vehicles. The latter include hormones, peptides, halogenated nucleotides, oligonucleotides and internalising antibodies
Keywords Auger radiation – Nuclear targeting – Treatment – Dosimetry
PMID: 16896663
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Research group Nutrition clinique (597)
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BUCHEGGER, Franz et al. Auger radiation targeted into DNA: a therapy perspective. In: European Journal of Nuclear Medicine and Molecular Imaging, 2006, vol. 33, n° 11, p. 1352-1363. https://archive-ouverte.unige.ch/unige:74269

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Deposited on : 2015-07-22

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