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Scientific article
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Short fluorodeoxyuridine exposure of different human glioblastoma lines induces high-level accumulation of S-phase cells that avidly incorporate 125I-iododeoxyuridine

Published inEuropean journal of nuclear medicine and molecular imaging, vol. 33, no. 5, p. 613-620
Publication date2006
Abstract

Radio-iododeoxyuridine (IdUrd) is a potential Auger radiation therapy agent incorporated into DNA during the synthesis phase. In this study we sought to optimise S-phase targeting by modulating cellular cycling and radio-IdUrd DNA incorporation using short non-toxic fluorodeoxyuridine (FdUrd) incubations. Methods: Three human glioblastoma cell lines with different p53 expression were pre-treated with various FdUrd conditions. After different intervals, 125I-IdUrd DNA incorporation was measured. Fluorescence-activated cell sorter cell cycle analysis was performed after identica

Keywords
  • Iododeoxyuridine
  • Fluorodeoxyuridine
  • S phase
  • Glioblastoma
  • Auger radiation
Citation (ISO format)
PERILLO-ADAMER, Florence et al. Short fluorodeoxyuridine exposure of different human glioblastoma lines induces high-level accumulation of S-phase cells that avidly incorporate 125I-iododeoxyuridine. In: European journal of nuclear medicine and molecular imaging, 2006, vol. 33, n° 5, p. 613–620. doi: 10.1007/s00259-005-0009-y
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ISSN of the journal1619-7070
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