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Title

Short fluorodeoxyuridine exposure of different human glioblastoma lines induces high-level accumulation of S-phase cells that avidly incorporate 125I-iododeoxyuridine

Authors
Perillo-Adamer, Florence
Bischof Delaloye, Angelika
Genton, Céline S.
Schaffland, Andreas O.
Published in European Journal of Nuclear Medicine and Molecular Imaging. 2006, vol. 33, no. 5, p. 613-620
Abstract Radio-iododeoxyuridine (IdUrd) is a potential Auger radiation therapy agent incorporated into DNA during the synthesis phase. In this study we sought to optimise S-phase targeting by modulating cellular cycling and radio-IdUrd DNA incorporation using short non-toxic fluorodeoxyuridine (FdUrd) incubations. Methods: Three human glioblastoma cell lines with different p53 expression were pre-treated with various FdUrd conditions. After different intervals, 125I-IdUrd DNA incorporation was measured. Fluorescence-activated cell sorter cell cycle analysis was performed after identica
Keywords Iododeoxyuridine – Fluorodeoxyuridine – S phase – Glioblastoma – Auger radiation
Identifiers
PMID: 16450135
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Research group Nutrition clinique (597)
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PERILLO-ADAMER, Florence et al. Short fluorodeoxyuridine exposure of different human glioblastoma lines induces high-level accumulation of S-phase cells that avidly incorporate 125I-iododeoxyuridine. In: European Journal of Nuclear Medicine and Molecular Imaging, 2006, vol. 33, n° 5, p. 613-620. https://archive-ouverte.unige.ch/unige:74268

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Deposited on : 2015-07-22

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