Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000

Marchetti, Oscar; Bille, Jacques; Fluckiger, Ursula; Eggimann, Philippe; Ruef, Christian; Garbino, Jorge; Calandra, Thierry; Glauser, M. P.; Tauber, M. G.; Pittet, Didier

doi:10.1086/380637

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Title		Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000
Authors		Marchetti, Oscar Bille, Jacques Fluckiger, Ursula Eggimann, Philippe Ruef, Christian Garbino, Jorge Calandra, Thierry Glauser, M. P. Tauber, M. G. Pittet, Didier show all authors [1 - 10]
Published in		Clinical Infectious Diseases. 2004, vol. 38, no. 3, p. 311-320
Abstract		Candida species are among the most common bloodstream pathogens in the United States, where the emergence of azole-resistant Candida glabrata and Candida krusei are major concerns. Recent comprehensive longitudinal data from Europe are lacking. We conducted a nationwide survey of candidemia during 1991-2000 in 17 university and university-affiliated hospitals representing 79% of all tertiary care hospital beds in Switzerland. The number of transplantations and bloodstream infections increased significantly (P<.001). A total of 1137 episodes of candidemia were observed: Candida species ranked seventh among etiologic agents (2.9% of all bloodstream isolates). The incidence of candidemia was stable over a 10-year period. C. albicans remained the predominant Candida species recovered (66%), followed by C. glabrata (15%). Candida tropicalis emerged (9%), the incidence of Candida parapsilosis decreased (1%), and recovery of C. krusei remained rare (2%). Fluconazole consumption increased significantly (P<.001). Despite increasing high-risk activities, the incidence of candidemia remained unchanged, and no shift to resistant species occurred.
Keywords		Antifungal Agents/therapeutic use — Candidiasis/drug therapy/ epidemiology — Cross Infection/drug therapy/ epidemiology/microbiology — Data Collection — Drug Resistance, Microbial — Fluconazole/therapeutic use — Fungemia/drug therapy/ epidemiology — Hospitals, University — Humans — Longitudinal Studies — Microbial Sensitivity Tests — Switzerland/epidemiology — United States/epidemiology
Identifiers		DOI: 10.1086/380637 PMID: 14727199
Full text		Article - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Staphylocoques dorés résistants à la méthicilline et hygiène hospitalière (330)
Citation (ISO format)		MARCHETTI, Oscar et al. Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000. In: Clinical Infectious Diseases, 2004, vol. 38, n° 3, p. 311-320. doi: 10.1086/380637 https://archive-ouverte.unige.ch/unige:7425