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Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000

Marchetti, Oscar
Bille, Jacques
Fluckiger, Ursula
Ruef, Christian
Calandra, Thierry
Glauser, M. P.
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Published in Clinical infectious diseases. 2004, vol. 38, no. 3, p. 311-320
Abstract Candida species are among the most common bloodstream pathogens in the United States, where the emergence of azole-resistant Candida glabrata and Candida krusei are major concerns. Recent comprehensive longitudinal data from Europe are lacking. We conducted a nationwide survey of candidemia during 1991-2000 in 17 university and university-affiliated hospitals representing 79% of all tertiary care hospital beds in Switzerland. The number of transplantations and bloodstream infections increased significantly (P<.001). A total of 1137 episodes of candidemia were observed: Candida species ranked seventh among etiologic agents (2.9% of all bloodstream isolates). The incidence of candidemia was stable over a 10-year period. C. albicans remained the predominant Candida species recovered (66%), followed by C. glabrata (15%). Candida tropicalis emerged (9%), the incidence of Candida parapsilosis decreased (1%), and recovery of C. krusei remained rare (2%). Fluconazole consumption increased significantly (P<.001). Despite increasing high-risk activities, the incidence of candidemia remained unchanged, and no shift to resistant species occurred.
Keywords Antifungal Agents/therapeutic useCandidiasis/drug therapy/ epidemiologyCross Infection/drug therapy/ epidemiology/microbiologyData CollectionDrug Resistance, MicrobialFluconazole/therapeutic useFungemia/drug therapy/ epidemiologyHospitals, UniversityHumansLongitudinal StudiesMicrobial Sensitivity TestsSwitzerland/epidemiologyUnited States/epidemiology
PMID: 14727199
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Research group Staphylocoques dorés résistants à la méthicilline et hygiène hospitalière (330)
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MARCHETTI, Oscar et al. Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends, 1991-2000. In: Clinical Infectious Diseases, 2004, vol. 38, n° 3, p. 311-320. doi: 10.1086/380637 https://archive-ouverte.unige.ch/unige:7425

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Deposited on : 2010-06-21

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