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Title

Modulating reconstituted high density lipoprotein functionality to target the Pseudomonas aeruginosa quorum sensing system

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Published in Life Sciences. 2014, vol. 112, no. 1-2, p. 68-73
Abstract The synthetic counterparts of serum high density lipoproteins (HDL; reconstituted HDL, reHDL) are assuming increasing importance as a therapeutic vector. They circulate not only in blood, but also outside the vascular compartment giving access to all body tissues. Presently, the therapeutic use of reHDL exploits inherent HDL functions. Our aim was to determine if HDL functionality could be modulated by attaching peptides not normally associated with the complex.
Keywords 4-Butyrolactone/analogs & derivatives/chemistryAryldialkylphosphatase/genetics/metabolismCulture Media, Conditioned/pharmacologyGene ExpressionHEK293 CellsHumansHydrolysisLipoproteins, HDL/genetics/metabolism/pharmacologyLiver/chemistry/enzymologyProtein EngineeringProtein Sorting Signals/geneticsPseudomonas aeruginosa/drug effects/growth & development/metabolismQuorum Sensing/drug effectsRecombinant Fusion Proteins/genetics/metabolism/pharmacology
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PMID: 25086378
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Structures
Research group Lipoprotéines sériques (598)
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DEAKIN, Sara Patricia et al. Modulating reconstituted high density lipoprotein functionality to target the Pseudomonas aeruginosa quorum sensing system. In: Life Sciences, 2014, vol. 112, n° 1-2, p. 68-73. https://archive-ouverte.unige.ch/unige:74190

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Deposited on : 2015-07-20

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