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Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial |
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Published in | Lancet oncology. 2015, vol. 16, no. 1, p. 47-56 | |
Abstract | Since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 Gy on overall survival, local control, and fibrosis for patients with stage I and II breast cancer who underwent breast-conserving treatment compared with patients who received no boost. Here, we present the 20-year follow-up results. | |
Keywords | Adult — Age Factors — Australia — Breast Neoplasms/mortality/pathology/radiotherapy/surgery — Europe — Female — Fibrosis — Humans — Intention to Treat Analysis — Israel — Kaplan-Meier Estimate — Mastectomy — Mastectomy, Segmental/adverse effects/mortality — Middle Aged — Neoplasm Recurrence, Local — Neoplasm Staging — Patient Selection — Proportional Hazards Models — Radiotherapy Dosage — Radiotherapy, Adjuvant — Reoperation — Salvage Therapy — Time Factors — Treatment Outcome | |
Identifiers | PMID: 25500422 | |
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Research group | Groupe Miralbell Raymond (radio-oncologie) (685) | |
Citation (ISO format) | BARTELINK, Harry et al. Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial. In: Lancet oncology, 2015, vol. 16, n° 1, p. 47-56. doi: 10.1016/S1470-2045(14)71156-8 https://archive-ouverte.unige.ch/unige:74124 |