Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial

Bartelink, Harry; Maingon, Philippe; Poortmans, Philip; Weltens, Caroline; Fourquet, Alain; Jager, Jos; Schinagl, Dominic; Oei, Bing; Rodenhuis, Carla; Horiot, Jean-Claude; Struikmans, Henk; Van Limbergen, Erik; Kirova, Youlia; Elkhuizen, Paula; Bongartz, Rudolf; Miralbell, Raymond; Morgan, David; Dubois, Jean-Bernard; Remouchamps, Vincent; Mirimanoff, René-Olivier; Collette, Sandra; Collette, Laurence

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Title		Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial
Authors		Bartelink, Harry Maingon, Philippe Poortmans, Philip Weltens, Caroline Fourquet, Alain Jager, Jos Schinagl, Dominic Oei, Bing Rodenhuis, Carla Horiot, Jean-Claude Struikmans, Henk Van Limbergen, Erik Kirova, Youlia Elkhuizen, Paula Bongartz, Rudolf Miralbell, Raymond Morgan, David Dubois, Jean-Bernard Remouchamps, Vincent Mirimanoff, René-Olivier Collette, Sandra Collette, Laurence show all authors [1 - 22]
Published in		The Lancet Oncology. 2015, vol. 16, no. 1, p. 47-56
Abstract		Since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 Gy on overall survival, local control, and fibrosis for patients with stage I and II breast cancer who underwent breast-conserving treatment compared with patients who received no boost. Here, we present the 20-year follow-up results.
Keywords		Adult — Age Factors — Australia — Breast Neoplasms/mortality/pathology/radiotherapy/surgery — Europe — Female — Fibrosis — Humans — Intention to Treat Analysis — Israel — Kaplan-Meier Estimate — Mastectomy — Mastectomy, Segmental/adverse effects/mortality — Middle Aged — Neoplasm Recurrence, Local — Neoplasm Staging — Patient Selection — Proportional Hazards Models — Radiotherapy Dosage — Radiotherapy, Adjuvant — Reoperation — Salvage Therapy — Time Factors — Treatment Outcome
Identifiers		DOI: 10.1016/S1470-2045(14)71156-8 PMID: 25500422
Full text		Article (Published version) (585 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Research group		Groupe Miralbell Raymond (radio-oncologie) (685)
Citation (ISO format)		BARTELINK, Harry et al. Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial. In: The Lancet Oncology, 2015, vol. 16, n° 1, p. 47-56. https://archive-ouverte.unige.ch/unige:74124