Scientific article
English

Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial

Published inLancet oncology, vol. 16, no. 1, p. 47-56
Publication date2015
Abstract

Since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 Gy on overall survival, local control, and fibrosis for patients with stage I and II breast cancer who underwent breast-conserving treatment compared with patients who received no boost. Here, we present the 20-year follow-up results.

Keywords
  • Adult
  • Age Factors
  • Australia
  • Breast Neoplasms/mortality/pathology/radiotherapy/surgery
  • Europe
  • Female
  • Fibrosis
  • Humans
  • Intention to Treat Analysis
  • Israel
  • Kaplan-Meier Estimate
  • Mastectomy
  • Mastectomy, Segmental/adverse effects/mortality
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Patient Selection
  • Proportional Hazards Models
  • Radiotherapy Dosage
  • Radiotherapy, Adjuvant
  • Reoperation
  • Salvage Therapy
  • Time Factors
  • Treatment Outcome
Citation (ISO format)
BARTELINK, Harry et al. Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial. In: Lancet oncology, 2015, vol. 16, n° 1, p. 47–56. doi: 10.1016/S1470-2045(14)71156-8
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN1470-2045
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