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Title

Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial

Authors
Bartelink, Harry
Maingon, Philippe
Poortmans, Philip
Weltens, Caroline
Fourquet, Alain
Jager, Jos
Schinagl, Dominic
Oei, Bing
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Published in The Lancet Oncology. 2015, vol. 16, no. 1, p. 47-56
Abstract Since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 Gy on overall survival, local control, and fibrosis for patients with stage I and II breast cancer who underwent breast-conserving treatment compared with patients who received no boost. Here, we present the 20-year follow-up results.
Keywords AdultAge FactorsAustraliaBreast Neoplasms/mortality/pathology/radiotherapy/surgeryEuropeFemaleFibrosisHumansIntention to Treat AnalysisIsraelKaplan-Meier EstimateMastectomyMastectomy, Segmental/adverse effects/mortalityMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPatient SelectionProportional Hazards ModelsRadiotherapy DosageRadiotherapy, AdjuvantReoperationSalvage TherapyTime FactorsTreatment Outcome
Identifiers
PMID: 25500422
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Research group Groupe Miralbell Raymond (radio-oncologie) (685)
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BARTELINK, Harry et al. Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial. In: The Lancet Oncology, 2015, vol. 16, n° 1, p. 47-56. https://archive-ouverte.unige.ch/unige:74124

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Deposited on : 2015-07-14

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