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Scientific article
English

Use of quinolones in osteomyelitis and infected orthopaedic prosthesis

Contributors

Lew, Daniel Pablo; Waldvogel, Francis

Published in

Drugs, vol. 58 Suppl 2, p. 85-91

Publication date

1999

Abstract

The present review provides an updated critical analysis of the use of quinolones in osteomyelitis and orthopaedic prosthetic infections. Only papers published in peer-reviewed journals and related to the following areas were selected: experimental osteomyelitis, penetration of quinolones into human bone, and clinical use in comparative and noncomparative studies. Local drug carriers impregnated with quinolones allow high local antibiotic concentrations to be achieved in experimental systems. Considerable clinical experience has been gained mostly with ciprofloxacin and ofloxacin. Cumulated results in clinical trials show clinical success rates of more than 90% in osteomyelitis caused by Enterobacteriaceae. The combination of quinolones and rifampicin for the treatment of staphylococcal osteomyelitis as well as orthopaedic prosthetic infections appears very promising in clinical studies with a small number of patients. However, further comparative studies using quinolones as single agents or in combination (versus standard parenteral therapy) remain necessary in osteomyelitis due to Staphylococcus aureus or Pseudomonas aeruginosa. In particular, studies with the newer quinolones should be strongly encouraged in acute or chronic osteomyelitis and in more complicated situations such as diabetic osteomyelitis or foreign-body infection.

Keywords

  • Animals
  • Anti-Infective Agents/ therapeutic use
  • Humans
  • Osteomyelitis/ drug therapy
  • Prosthesis-Related Infections/ drug therapy

UNIGE affiliation entities

Citation (ISO format)

LEW, Daniel Pablo, WALDVOGEL, Francis. Use of quinolones in osteomyelitis and infected orthopaedic prosthesis. In: Drugs, 1999, vol. 58 Suppl 2, p. 85–91. doi: 10.2165/00003495-199958002-00017

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Additional URL for this publication

http://adisonline.com/drugs/Citation/1999/58002/Use_of_Quinolones_in_Osteomyelitis_and_Infected.17.aspx

Journal ISSN

0012-6667
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Technical informations

Creation

21/06/2010 10:25:15

First validation

21/06/2010 10:25:15

Update

14/03/2023 15:44:35

Status update

14/03/2023 15:44:35

Last indexation

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