Scientific article

High levels of complement breakdown products in tuberculous pleural effusions

Published inClinical and experimental immunology, vol. 52, no. 3, p. 569-574
Publication date1983

Pleural fluids from 10 patients with tuberculous pleural effusions contained high levels of small molecular weight breakdown products of C3 (C3d) and of properdin factor B (Ba) when compared to 16 patients with effusions of neoplastic origin (P less than 0.001). The same fluids exhibited overlapping values of haemolytic factor B, classical or alternative pathway-mediated haemolytic activity and native C3. A significant correlation between Ba and lysozyme levels was found in all effusions tested (P less than 0.05). These findings suggest that activation of the complement system is an important aspect of the extensive inflammation and tissue destruction characteristic of human tuberculosis.

  • Complement Activation
  • Complement C3/ analysis
  • Complement C3d
  • Complement Factor B/ analysis
  • Enzyme Precursors/ analysis
  • Female
  • Humans
  • Neoplasms/immunology
  • Pleural Effusion/etiology/ immunology
  • Prospective Studies
  • Tuberculosis, Pleural/ immunology
Citation (ISO format)
LEW, Daniel Pablo et al. High levels of complement breakdown products in tuberculous pleural effusions. In: Clinical and experimental immunology, 1983, vol. 52, n° 3, p. 569–574.
Updates (1)
ISSN of the journal0009-9104

Technical informations

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