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High levels of complement breakdown products in tuberculous pleural effusions

Perrin, L. H.
Published in Clinical and experimental immunology. 1983, vol. 52, no. 3, p. 569-574
Abstract Pleural fluids from 10 patients with tuberculous pleural effusions contained high levels of small molecular weight breakdown products of C3 (C3d) and of properdin factor B (Ba) when compared to 16 patients with effusions of neoplastic origin (P less than 0.001). The same fluids exhibited overlapping values of haemolytic factor B, classical or alternative pathway-mediated haemolytic activity and native C3. A significant correlation between Ba and lysozyme levels was found in all effusions tested (P less than 0.05). These findings suggest that activation of the complement system is an important aspect of the extensive inflammation and tissue destruction characteristic of human tuberculosis.
Keywords Complement ActivationComplement C3/ analysisComplement C3dComplement Factor B/ analysisEnzyme Precursors/ analysisFemaleHumansNeoplasms/immunologyPleural Effusion/etiology/ immunologyProspective StudiesTuberculosis, Pleural/ immunology
PMID: 6603298
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LEW, Daniel Pablo et al. High levels of complement breakdown products in tuberculous pleural effusions. In: Clinical and experimental immunology, 1983, vol. 52, n° 3, p. 569-574. https://archive-ouverte.unige.ch/unige:7404

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Deposited on : 2010-06-21

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