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Title

Molecular epidemiology reveals long-term changes in HIV type 1 subtype B transmission in Switzerland

Authors
Kouyos, R. D.
von Wyl, Viktor
Boni, Jurg
Shah, Cyril
Burgisser, Philippe
Klimkait, Thomas
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Published in The Journal of Infectious Diseases. 2010, vol. 201, no. 10, p. 1488-1497
Abstract BACKGROUND: Sequence data from resistance testing offer unique opportunities to characterize the structure of human immunodeficiency virus (HIV) infection epidemics. METHODS: We analyzed a representative set of HIV type 1 (HIV-1) subtype B pol sequences from 5700 patients enrolled in the Swiss HIV Cohort Study. We pooled these sequences with the same number of sequences from foreign epidemics, inferred a phylogeny, and identified Swiss transmission clusters as clades having a minimal size of 10 and containing >or=80% Swiss sequences. RESULTS: More than one-half of Swiss patients were included within 60 transmission clusters. Most transmission clusters were significantly dominated by specific transmission routes, which were used to identify the following patient groups: men having sex with men (MSM) (38 transmission clusters; average cluster size, 29 patients) or patients acquiring HIV through heterosexual contact (HETs) and injection drug users (IDUs) (12 transmission clusters; average cluster size, 144 patients). Interestingly, there were no transmission clusters dominated by sequences from HETs only. Although 44% of all HETs who were infected between 1983 and 1986 clustered with injection drug users, this percentage decreased to 18% for 2003-2006 (P<.001), indicating a diminishing role of injection drug users in transmission among HETs over time. CONCLUSIONS: Our analysis suggests (1) the absence of a self-sustaining epidemic of HIV-1 subtype B in HETs in Switzerland and (2) a temporally decreasing clustering of HIV infections in HETs and IDUs.
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PMID: 20384495
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Other version: http://www.journals.uchicago.edu/doi/pdf/10.1086/651951
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KOUYOS, R. D. et al. Molecular epidemiology reveals long-term changes in HIV type 1 subtype B transmission in Switzerland. In: The Journal of Infectious Diseases, 2010, vol. 201, n° 10, p. 1488-1497. https://archive-ouverte.unige.ch/unige:7390

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Deposited on : 2010-06-21

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