Advanced fibrosis: Correlation between pharmacokinetic parameters at dynamic gadoxetate-enhanced MR imaging and hepatocyte organic anion transporter expression in rat liver

Lagadec, Matthieu; Doblas, Sabrina; Giraudeau, Céline; Ronot, Maxime; Lambert, Simon A; Fasseu, Magali; Paradis, Valérie; Moreau, Richard; Pastor, Catherine; Vilgrain, Valérie; Daire, Jean-Luc; Van Beers, Bernard E

doi:10.1148/radiol.14140313

Scientific article

English

Advanced fibrosis: Correlation between pharmacokinetic parameters at dynamic gadoxetate-enhanced MR imaging and hepatocyte organic anion transporter expression in rat liver

ContributorsLagadec, Matthieu; Doblas, Sabrina; Giraudeau, Céline; Ronot, Maxime; Lambert, Simon A; Fasseu, Magali; Paradis, Valérie; Moreau, Richard; Pastor, Catherine

; Vilgrain, Valérie; Daire, Jean-Luc; Van Beers, Bernard E

Published inRadiology, vol. 274, no. 2, p. 379-386

Publication date2015

Abstract

To compare the value of enhancement and pharmacokinetic parameters measured at dynamic gadoxetate-enhanced magnetic resonance (MR) imaging in determining hepatic organic anion transporter expression in control rats and rats with advanced liver fibrosis.

Keywords

Animals
Contrast Media/pharmacokinetics
Gadolinium DTPA/diagnostic use/pharmacokinetics
Hepatocytes/metabolism
Liver Cirrhosis/diagnosis/metabolism
Magnetic Resonance Imaging
Multidrug Resistance-Associated Proteins
Organic Anion Transporters/biosynthesis
Rats
Rats, Wistar
Severity of Illness Index

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Research groups

Pharmacologie et imagerie du foie (664)

Citation (ISO format)

LAGADEC, Matthieu et al. Advanced fibrosis: Correlation between pharmacokinetic parameters at dynamic gadoxetate-enhanced MR imaging and hepatocyte organic anion transporter expression in rat liver. In: Radiology, 2015, vol. 274, n° 2, p. 379–386. doi: 10.1148/radiol.14140313

Article (Published version)

Identifiers

PID : unige:73853
DOI : 10.1148/radiol.14140313
PMID : 25289480

Journal ISSN0033-8419

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Creation29/06/2015 17:24:00

First validation29/06/2015 17:24:00

Update14/03/2023 23:26:07

Status update14/03/2023 23:26:06

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Advanced fibrosis: Correlation between pharmacokinetic parameters at dynamic gadoxetate-enhanced MR imaging and hepatocyte organic anion transporter expression in rat liver

To compare the value of enhancement and pharmacokinetic parameters measured at dynamic gadoxetate-enhanced magnetic resonance (MR) imaging in determining hepatic organic anion transporter expression in control rats and rats with advanced liver fibrosis.

Technical informations