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Effect of hyperthermia on NF-kappaB binding activity in cerulein-induced acute pancreatitis

Published in American Journal of Physiology. Gastrointestinal and Liver Physiology. 2001, vol. 280, no. 6, p. G1157-62
Abstract Although the pancreatic heat shock response has already been reported to confer protective effects during experimental pancreatitis, the mechanism of action remains unknown. We investigated the effects of hyperthermia in cerulein-induced pancreatitis. Heat shock protein 70 (HSP70) expression in rats was induced by a 20-min period of water immersion (42 degrees C). The severity of pancreatitis as well as the pancreatic expression of cytokines, nuclear factor-kappaB (NF-kappaB), and inhibitory factor kappaB-alpha (IkappaB-alpha) were evaluated in the presence and absence of hyperthermia. We found that hyperthermia resulted in time-dependent expression of HSP70 within the pancreas associated with a reduction in the severity of acute pancreatitis. Tumor necrosis factor-alpha and intercellular adhesion molecule-1 expression was significantly reduced in the presence of hyperthermia. Moreover, NF-kappaB activity was delayed in the presence of hyperthermia whereas IkappaB-alpha was stabilized in the cytoplasm. These results suggest that hyperthermia decreases the severity of cerulein-induced pancreatitis by decreasing cytokine expression in the pancreas through the modulation of NF-kappaB activity.
Keywords Acute DiseaseAnimalsCeruletideFever/metabolismHSP70 Heat-Shock Proteins/metabolismIntercellular Adhesion Molecule-1/metabolismMaleNF-kappa B/metabolismOsmolar ConcentrationPancreatitis/chemically induced/metabolismRatsRats, WistarReference ValuesTumor Necrosis Factor-alpha/metabolism
PMID: 11352808
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Research groups Pharmacologie et imagerie du foie (664)
Physiopathologie de la pancréatite aiguë (601)
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FROSSARD, Jean-Louis, PASTOR, Catherine, HADENGUE, Antoine. Effect of hyperthermia on NF-kappaB binding activity in cerulein-induced acute pancreatitis. In: American Journal of Physiology. Gastrointestinal and Liver Physiology, 2001, vol. 280, n° 6, p. G1157-62. https://archive-ouverte.unige.ch/unige:73842

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Deposited on : 2015-07-02

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