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Effects of glucose on chemically induced acute hepatic failure in rats

Published in European journal of pediatric surgery. 1998, vol. 8, no. 5, p. 282-7
Abstract Acute hepatic failure (AHF) is a physiopathological entity difficult to reproduce experimentally but necessary to evaluate new therapies such as bioartificial liver (BAL) or hepatocyte transplantation (HcTX). Two main animal models are available: surgical or chemical induction of an AHF. Many authors have assessed BAL or HcTX with such models and observed increased survival rate in the treated groups. However, during AHF, severe hypoglycemia takes place. Some authors have shown that adjunction of glucose in beverage after surgically induced AHF may induce by itself an improvement of survival rate.
Keywords AnimalsDisease Models, AnimalGlucose/therapeutic useLiver Failure, Acute/drug therapy/physiopathologyLiver Function TestsMaleRatsRats, WistarReproducibility of Results
PMID: 9825238
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Research groups Chirurgie viscérale (104)
Chirurgie viscérale (HUG)
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BIRRAUX, Jacques Maurice et al. Effects of glucose on chemically induced acute hepatic failure in rats. In: European journal of pediatric surgery, 1998, vol. 8, n° 5, p. 282-7. doi: 10.1055/s-2008-1071215 https://archive-ouverte.unige.ch/unige:73814

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Deposited on : 2015-07-02

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