Scientific article

Effects of glucose on chemically induced acute hepatic failure in rats

Published inEuropean journal of pediatric surgery, vol. 8, no. 5, p. 282-287
Publication date1998

Acute hepatic failure (AHF) is a physiopathological entity difficult to reproduce experimentally but necessary to evaluate new therapies such as bioartificial liver (BAL) or hepatocyte transplantation (HcTX). Two main animal models are available: surgical or chemical induction of an AHF. Many authors have assessed BAL or HcTX with such models and observed increased survival rate in the treated groups. However, during AHF, severe hypoglycemia takes place. Some authors have shown that adjunction of glucose in beverage after surgically induced AHF may induce by itself an improvement of survival rate.

  • Animals
  • Disease Models, Animal
  • Glucose/therapeutic use
  • Liver Failure, Acute/drug therapy/physiopathology
  • Liver Function Tests
  • Male
  • Rats
  • Rats, Wistar
  • Reproducibility of Results
Citation (ISO format)
BIRRAUX, Jacques Maurice et al. Effects of glucose on chemically induced acute hepatic failure in rats. In: European journal of pediatric surgery, 1998, vol. 8, n° 5, p. 282–287. doi: 10.1055/s-2008-1071215
Main files (1)
Article (Published version)
ISSN of the journal0939-7248

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