en
Scientific article
English

Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up

CollaboratorsChizzolini, Carlo
Published inAnnals of the rheumatic diseases, vol. 71, no. 6, p. 955-960
Publication date2012
Abstract

The previously reported randomised controlled trial of a consensus regimen of pulse cyclophosphamide suggested that it was as effective as a daily oral (DO) cyclophosphamide for remission induction of antineutrophil cytoplasm autoantibodies-associated systemic vasculitis when both were combined with the same glucocorticoid protocol (CYCLOPS study (Randomised trial of daily oral versus pulse Cyclophosphamide as therapy for ANCA-associated Systemic Vasculitis published de groot K, harper L et al Ann Int Med 2009)). The study had limited power to detect a difference in relapse. This study describes the long-term outcomes of patients in the CYCLOPS study.

Keywords
  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Antineutrophil Cytoplasmic/immunology
  • Cyclophosphamide/administration & dosage
  • Female
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents/administration & dosage
  • Kidney/physiology
  • Male
  • Middle Aged
  • Pulse Therapy, Drug
  • Remission Induction
  • Retrospective Studies
  • Risk Factors
  • Secondary Prevention
  • Time Factors
  • Vasculitis/drug therapy/immunology/mortality
  • Young Adult
Citation (ISO format)
HARPER, Lorraine et al. Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up. In: Annals of the rheumatic diseases, 2012, vol. 71, n° 6, p. 955–960. doi: 10.1136/annrheumdis-2011-200477
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0003-4967
502views
0downloads

Technical informations

Creation06/30/2015 4:03:00 PM
First validation06/30/2015 4:03:00 PM
Update time03/14/2023 11:25:17 PM
Status update03/14/2023 11:25:16 PM
Last indexation01/16/2024 6:25:47 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack