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Title

Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up

Authors
Harper, Lorraine
Morgan, Matthew D
Walsh, Michael
Hoglund, Peter
Westman, Kerstin
Flossmann, Oliver
Tesar, Vladimir
Vanhille, Phillipe
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CollaborationWith : Chizzolini, Carlo
Published in Annals of the Rheumatic Diseases. 2012, vol. 71, no. 6, p. 955-60
Abstract The previously reported randomised controlled trial of a consensus regimen of pulse cyclophosphamide suggested that it was as effective as a daily oral (DO) cyclophosphamide for remission induction of antineutrophil cytoplasm autoantibodies-associated systemic vasculitis when both were combined with the same glucocorticoid protocol (CYCLOPS study (Randomised trial of daily oral versus pulse Cyclophosphamide as therapy for ANCA-associated Systemic Vasculitis published de groot K, harper L et al Ann Int Med 2009)). The study had limited power to detect a difference in relapse. This study describes the long-term outcomes of patients in the CYCLOPS study.
Keywords Administration, OralAdolescentAdultAgedAged, 80 and overAntibodies, Antineutrophil Cytoplasmic/immunologyCyclophosphamide/administration & dosageFemaleFollow-Up StudiesHumansImmunosuppressive Agents/administration & dosageKidney/physiologyMaleMiddle AgedPulse Therapy, DrugRemission InductionRetrospective StudiesRisk FactorsSecondary PreventionTime FactorsVasculitis/drug therapy/immunology/mortalityYoung Adult
Identifiers
PMID: 22128076
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Research group La matrice extracellulaire (651)
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HARPER, Lorraine et al. Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up. In: Annals of the Rheumatic Diseases, 2012, vol. 71, n° 6, p. 955-60. https://archive-ouverte.unige.ch/unige:73764

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Deposited on : 2015-06-30

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