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Mucocutaneous papillomatous papules in Cowden's syndrome

Jornayvaz, F R.
Published in Clinical and Experimental Dermatology. 2008, vol. 33, no. 2, p. 151-3
Abstract Cowden syndrome (CS; also known as multiple hamartoma syndrome) is a rare autosomal dominant disorder characterized by multiple hamartomas and a high risk of development of thyroid, breast, endometrial and other cancers. The cardinal features of the disease, which often lead to diagnosis, include mucocutaneous papillomatous papules and trichilemmomas. Most affected people develop these characteristic lesions by the age of 20 years. Once diagnosed, gene identification can be offered to family members of affected patients. We report a case of the disease and briefly review the current literature.
Keywords AdultAge FactorsFemaleHamartoma Syndrome Multiple/genetics/pathologyHumansMonitoring ImmunologicPTEN Phosphohydrolase/genetics/metabolismPapilloma/diagnosis/geneticsPrecancerous Conditions/genetics/pathologyThyroid Gland/pathology/surgeryThyroidectomy/methodsTreatment Outcome
PMID: 18021272
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Research group Diabète et régulation des gènes (36)
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JORNAYVAZ, F R., PHILIPPE, Jacques. Mucocutaneous papillomatous papules in Cowden's syndrome. In: Clinical and Experimental Dermatology, 2008, vol. 33, n° 2, p. 151-3. https://archive-ouverte.unige.ch/unige:736

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Deposited on : 2009-02-09

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