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Title

Detection of enteroviruses in the cerebrospinal fluid by polymerase chain reaction: prospective study of impact on the management of hospitalized children

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Published in Clinical Pediatrics. 2000, vol. 39, no. 4, p. 203-8
Abstract A polymerase chain reaction kit (AMPLICOR EV) for the detection of enteroviruses (EV-PCR) in the cerebrospinal fluid (CSF) was evaluated in clinical conditions in a prospective blinded-intention study. Forty-three children (mean age 2.7 years) hospitalized for suspected meningitis or fever of unclear etiology were enrolled. EV-PCR was performed on a daily basis. Results were available in less than 2 days in 72% of cases. EV-PCR was positive in nine (21%) children, including three infants without CSF pleocytosis. Knowing their EV-PCR result would have allowed a saving of 18 hospital days and 12 days of antibiotic therapy. The EV-PCR in the CSF can thus be practically useful for children hospitalized for meningitis or fever if available on-site on a daily basis.
Keywords AdolescentCerebrospinal Fluid/virologyChildChild, PreschoolDiagnosis, DifferentialEnterovirus Infections/cerebrospinal fluidEvaluation Studies as TopicFemaleFever of Unknown Origin/cerebrospinal fluid/microbiologyHumansInfantInfant, NewbornLength of StayMaleMeningitis, Viral/cerebrospinal fluid/microbiologyPolymerase Chain Reaction/methodsProspective Studies
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PMID: 10791131
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Article (Published version) (3.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Centre de Vaccinologie et d'Immunologie néonatale (177)
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MASSEREY SPICHER, Virginie et al. Detection of enteroviruses in the cerebrospinal fluid by polymerase chain reaction: prospective study of impact on the management of hospitalized children. In: Clinical Pediatrics, 2000, vol. 39, n° 4, p. 203-8. https://archive-ouverte.unige.ch/unige:73174

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Deposited on : 2015-06-10

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